Relationships between chromosome damage, cell cycle delay and cell killing induced by bleomycin or X-rays

The extent of mitotic delay and chromosome aberration induction by X-rays and bleomycin has been compared in normal human foetal fibroblasts at doses giving approximately equal levels of cell killing, assayed as colony-forming ability. Bleomycin induced much less G2 delay and chromosome damage than...

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Bibliographic Details
Published inMutation research Vol. 151; no. 1; p. 83
Main Authors Scott, D, Zampetti-Bosseler, F
Format Journal Article
LanguageEnglish
Published Netherlands 01.01.1985
Subjects
Bleomycin - toxicity
Cell Cycle - drug effects
Cell Cycle - radiation effects
Cell Survival - drug effects
Cell Survival - radiation effects
Chromosome Aberrations
Chromosomes - radiation effects
Extrachromosomal Inheritance
Humans
Mitosis - drug effects
Mitosis - radiation effects
X-Rays
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Summary:The extent of mitotic delay and chromosome aberration induction by X-rays and bleomycin has been compared in normal human foetal fibroblasts at doses giving approximately equal levels of cell killing, assayed as colony-forming ability. Bleomycin induced much less G2 delay and chromosome damage than X-rays. We conclude that the major mechanism of cell killing by bleomycin does not involve chromosome damage but the cells pass through a number of division cycles before dying and a common DNA lesion is involved in G2 delay and chromosome damage.
ISSN:0027-5107
DOI:10.1016/0027-5107(85)90186-1