Axonal and presynaptic FMRP: Localization, signal, and functional implications

• Published in: Hearing research Vol. 430; p. 108720
• Main Authors: Wang, Xiaoyu, Sela-Donenfeld, Dalit, Wang, Yuan
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 15.03.2023
• Subjects: Axon projection development; Axonal granules; Axons; Fragile X mental retardation protein; Fragile X Mental Retardation Protein - genetics; Fragile X Mental Retardation Protein - metabolism; Humans; Neurons - metabolism; Neuropsychiatric disorders; Neurotransmitter release; Presynaptic Terminals - metabolism; RNA-binding proteins; Synapses - physiology; Axonal granules; Fragile X mental retardation protein; Neurotransmitter release; RNA-binding proteins; Neuropsychiatric disorders; Axon projection development
• ISSN: 0378-5955; 1878-5891
• DOI: 10.1016/j.heares.2023.108720

·Fragile X mental retardation protein (FMRP) binds a selected set of mRNAs and proteins to guide neural circuit assembly and regulate synaptic plasticity.·Loss of FMRP is responsible for Fragile X syndrome, a neuropsychiatric disorder characterized with auditory processing problems and social difficulty.·FMRP actions in synaptic formation, maturation, and plasticity are site-specific among the four compartments of a synapse: presynaptic and postsynaptic neurons, astrocytes, and extracellular matrix.·This review summarizes advancements in understanding FMRP localization, signals, and functional roles in axons and presynaptic terminals, and discussed the axonal FMRP in auditory function and disease. Fragile X mental retardation protein (FMRP) binds a selected set of mRNAs and proteins to guide neural circuit assembly and regulate synaptic plasticity. Loss of FMRP is responsible for Fragile X syndrome, a neuropsychiatric disorder characterized with auditory processing problems and social difficulty. FMRP actions in synaptic formation, maturation, and plasticity are site-specific among the four compartments of a synapse: presynaptic and postsynaptic neurons, astrocytes, and extracellular matrix. This review summarizes advancements in understanding FMRP localization, signals, and functional roles in axons and presynaptic terminals.