Tiotropium in Early-Stage Chronic Obstructive Pulmonary Disease

• Published in: The New England journal of medicine Vol. 377; no. 10; pp. 923 - 935
• Main Authors: Zhou, Yumin, Zhong, Nan-shan, Li, Xiaochen, Chen, Shuyun, Zheng, Jinping, Zhao, Dongxing, Yao, Weimin, Zhi, Rongchang, Wei, Liping, He, Bingwen, Zhang, Xiangyan, Yang, Changli, Li, Ying, Li, Fenglei, Du, Juan, Gui, Jianping, Hu, Bin, Bai, Chunxue, Huang, Ping, Chen, Gang, Xu, Yongjian, Wang, Changzheng, Liang, Biao, Li, Yinhuan, Hu, Guoping, Tan, Hui, Ye, Xianwei, Ma, Xitao, Chen, Yan, Hu, Xiwei, Tian, Jia, Zhu, Xiaodan, Shi, Zhe, Du, Xiufang, Li, Minjing, Liu, Shengming, Yu, Ronghuan, Zhao, Jianping, Ma, Qianli, Xie, Canmao, Li, Xiongbin, Chen, Tao, Lin, Yingxiang, Zeng, Lizhen, Ye, Changxiu, Ye, Weishu, Luo, Xiangwen, Zeng, Lingshan, Yu, Shuqing, Guan, Wei-jie, Ran, Pixin
• Format: Journal Article
• Language: English
• Published: United States Massachusetts Medical Society 07.09.2017
• Subjects: Administration, Inhalation; Aged; Bronchodilator Agents - adverse effects; Bronchodilator Agents - therapeutic use; Bronchodilators; Chronic obstructive pulmonary disease; Clinical trials; Disease Progression; Double-Blind Method; Drug therapy; Female; Forced Expiratory Volume - drug effects; Humans; Lung diseases; Male; Middle Aged; Obstructive lung disease; Pharmaceuticals; Pulmonary Disease, Chronic Obstructive - drug therapy; Pulmonary Disease, Chronic Obstructive - physiopathology; Quality of Life; Respiratory function; Tiotropium Bromide - adverse effects; Tiotropium Bromide - therapeutic use
• ISSN: 0028-4793; 1533-4406; 1533-4406
• DOI: 10.1056/NEJMoa1700228

Patients with early-stage COPD were assigned to usual care plus tiotropium or placebo. Tiotropium resulted in better FEV 1 values. The annual decline in the prebronchodilator FEV 1 was similar in the two groups, but a benefit from tiotropium was seen in postbronchodilator FEV 1 .