Clotting profile in cattle showing chronic enzootic haematuria (CEH) and bladder neoplasms

Primary haemostasis (bleeding and blood clotting time), activated partial thromboplastin time (APTT), prothrombin time (PT), antithrombin III (ATIII), protein C, protein S, fibrinogen and D-dimer were determined in 13 cattle affected by chronic enzootic haematuria (CEH) and bladder neoplasms and 10...

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Published inResearch in veterinary science Vol. 93; no. 1; pp. 331 - 335
Main Authors Di Loria, A., Piantedosi, D., Cortese, L., Roperto, S., Urraro, C., Paciello, O., Guccione, J., Britti, D., Ciaramella, P.
Format Journal Article
LanguageEnglish
Published England Elsevier India Pvt Ltd 01.08.2012
Elsevier Limited
Subjects
Angiogenesis
Animals
Antithrombin III - analysis
Bladder
Blood
Blood Coagulation
Bovine
Bracken fern
Cancer
Cattle
Cattle Diseases - blood
Cattle Diseases - pathology
Clotting profile
Enzootic
Fibrin Fibrinogen Degradation Products - analysis
Fibrinogen - analysis
Haematuria
Hematuria - blood
Hematuria - veterinary
Hemostasis
HIV
Human immunodeficiency virus
Partial Thromboplastin Time - veterinary
Protein C - analysis
Protein S - analysis
Prothrombin Time - veterinary
Standard deviation
Tumors
Urinary Bladder - pathology
Urinary Bladder Neoplasms - blood
Urinary Bladder Neoplasms - pathology
Urinary Bladder Neoplasms - veterinary
Veterinary medicine
Viral infections
Haematuria
Enzootic
Bracken fern
Clotting profile
Bovine
Cancer
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Summary:Primary haemostasis (bleeding and blood clotting time), activated partial thromboplastin time (APTT), prothrombin time (PT), antithrombin III (ATIII), protein C, protein S, fibrinogen and D-dimer were determined in 13 cattle affected by chronic enzootic haematuria (CEH) and bladder neoplasms and 10 healthy cattle (control group). Increases in antithrombin III and protein S activities (P<0.01) and protein C and fibrinogen plasma levels (P<0.05) were observed in sick animals, while activated partial thromboplastin time, prothrombin time, and D-dimer did not show significant differences when compared to healthy animals. The clotting profile observed does not seem responsible for the chronic bleeding typical of CEH. The observed modification of some coagulation markers may derive from multiple interactions among cancer, inflammation and viral infection status typical of this syndrome.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0034-5288
1532-2661
DOI:10.1016/j.rvsc.2011.07.011