Non-targeted bystander effects induced by ionizing radiation

Radiation-induced bystander effects refer to those responses occurring in cells that were not subject to energy deposition events following ionizing radiation. These bystander cells may have been neighbors of irradiated cells, or physically separated but subject to soluble secreted signals from irra...

Full description

Saved in:
Bibliographic Details
Published inMutation Research-Fundamental and Molecular Mechanisms of Mutagenesis Vol. 616; no. 1-2; pp. 159 - 164
Main Authors Morgan, William F, Sowa, Marianne B
Format Journal Article
LanguageEnglish
Published Netherlands 01.03.2007
Subjects
Animals
Bystander Effect
Chromosome Aberrations - radiation effects
Cricetinae
Dose-Response Relationship, Radiation
Genomic Instability
Humans
Mice
Radiation, Ionizing
Risk Assessment
Signal Transduction
Online AccessGet full text

Cover

More Information
Summary:Radiation-induced bystander effects refer to those responses occurring in cells that were not subject to energy deposition events following ionizing radiation. These bystander cells may have been neighbors of irradiated cells, or physically separated but subject to soluble secreted signals from irradiated cells. Bystander effects have been observed in vitro and in vivo and for various radiation qualities. In tribute to an old friend and colleague, Anthony V. Carrano, who would have said "well what are the critical questions that should be addressed, and so what?", we review the evidence for non-targeted radiation-induced bystander effects with emphasis on prevailing questions in this rapidly developing research field, and the potential significance of bystander effects in evaluating the detrimental health effects of radiation exposure.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0027-5107
1386-1964
0027-5107
DOI:10.1016/j.mrfmmm.2006.11.009