The Obscure Potential of AHNAK2

AHNAK2 is a protein discovered in 2004, with a strong association with oncogenesis in various epithelial cancers. It has a large 616 kDa tripartite structure and is thought to take part in the formation of large multi-protein complexes. High expression is found in clear cell renal carcinoma, pancrea...

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Bibliographic Details
Published inCancers Vol. 14; no. 3; p. 528
Main Authors Zardab, Mohamed, Stasinos, Konstantinos, Grose, Richard P, Kocher, Hemant M
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 21.01.2022
MDPI
Subjects
Adenocarcinoma
Amino acids
Binding sites
Cancer
Cardiomyocytes
Clear cell-type renal cell carcinoma
Cytoplasm
Glucose
Kinases
Localization
Lymphatic system
Medical prognosis
Melanoma
Metastasis
Musculoskeletal system
Nervous system
Pancreatic carcinoma
Peptides
Phosphorylation
Proteins
Review
Smooth muscle
Therapeutic targets
Tumorigenesis
screening
cancer
AHNAK
biomarker
AHNAK2
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Summary:AHNAK2 is a protein discovered in 2004, with a strong association with oncogenesis in various epithelial cancers. It has a large 616 kDa tripartite structure and is thought to take part in the formation of large multi-protein complexes. High expression is found in clear cell renal carcinoma, pancreatic ductal adenocarcinoma, uveal melanoma, and lung adenocarcinoma, with a relation to poor prognosis. Little work has been done in exploring the function and relation AHNAK2 has with cancer, with early studies showing promising potential as a future biomarker and therapeutic target.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
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ObjectType-Review-1
ISSN:2072-6694
2072-6694
DOI:10.3390/cancers14030528