Osteomesopyknosis: Report of a new case with bone histology

• Published in: Bone (New York, N.Y.) Vol. 15; no. 1; pp. 81 - 83
• Main Authors: Hardouin, P., Flautre, B., Sutter, B., Leclet, H., Grardel, B., Fauquert, P.
• Format: Journal Article Conference Proceeding
• Language: English
• Published: New York, NY Elsevier Inc 1994; Elsevier Science
• Subjects: Biological and medical sciences; Bone and Bones - diagnostic imaging; Bone and Bones - pathology; Diseases of the osteoarticular system; Genes, Dominant; Humans; Male; Malformations and congenital and or hereditary diseases involving bones. Joint deformations; Medical sciences; Microradiography; Middle Aged; Osteomesopyknosis; Osteosclerosis; Osteosclerosis - diagnostic imaging; Osteosclerosis - genetics; Osteosclerosis - pathology; Pedigree; Radiography; Osteosclerosis; Osteomesopyknosis; Microradiography; Human; Diseases of the osteoarticular system; Exploration; Inorganic element; Genetic disease; Case study; Pathology; Content; Diagnosis; Bone; Osteochondrodysplasia
• ISSN: 8756-3282; 1873-2763
• DOI: 10.1016/8756-3282(94)90895-8

A new case of osteomesopyknosis, a rare autosomal dominant axial osteosclerosis is reported, with 4 affected members of the same family. Biochemical investigations, bone mineral content (BMC) measurement, 99mTc HMDP bone scan and microscopy of iliac crest bone and femoral head have been performed on 1 subject. A marked increase of BMC was found, without abnormality of biochemical data. Microscopy of bone showed an increase of trabecular thickness, and a low rate of bone turnover. No abnormality of mineralization was found on microradiographs.