Thermoregulatory effect of intracerebral injections of neuropeptide Y in rats at different environmental temperatures

1. In order to characterize the thermoregulatory actions of brain neuropeptide Y (NPY), the effects of intra-third ventricular (I3V) injection of NPY on temperatures of colon (Tco), brown adipose tissue (TBAT) and tail skin (Ts) were observed at ambient temperatures (Ta) of 19 and 8 degrees C. 2. Th...

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Bibliographic Details
Published inGeneral pharmacology Vol. 25; no. 1; p. 85
Main Authors Szreder, Z, Hori, T, Kaizuka, Y
Format Journal Article
LanguageEnglish
Published England 01.01.1994
Subjects
Adipose Tissue, Brown - metabolism
Animals
Body Temperature Regulation - drug effects
Body Temperature Regulation - physiology
Brain - drug effects
Brain - physiology
Cold Temperature
Injections, Intraventricular
Male
Neuropeptide Y - pharmacology
Neuropeptide Y - physiology
Rats
Rats, Wistar
Rectum - physiology
Temperature
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Summary:1. In order to characterize the thermoregulatory actions of brain neuropeptide Y (NPY), the effects of intra-third ventricular (I3V) injection of NPY on temperatures of colon (Tco), brown adipose tissue (TBAT) and tail skin (Ts) were observed at ambient temperatures (Ta) of 19 and 8 degrees C. 2. The injection of NPY in a dose of 8 mcg/100 g body wt evoked a fall of Tco by about 2 degrees C in both neutral and cold environments. NPY (4 and 8 mcg/100 g body wt) induced dose-dependent Tco falls in rats at thermoneutral environment. The thermolytic reactions induced by I3V administration of NPY were associated with a fall in TBAT but no changes in Is were observed. 3. The results suggest that NPY may mediate hypothermic response in neutral and cold environments mainly by its effects on the brown adipose tissues in the rat.
ISSN:0306-3623
DOI:10.1016/0306-3623(94)90014-0