Type A CCK receptors mediate satiety effects of intestinal nutrients

• Published in: Pharmacology, biochemistry and behavior Vol. 54; no. 3; pp. 625 - 631
• Main Authors: Brenner, Lynne A., Ritter, Robert C.
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 01.07.1996; Elsevier Science
• Subjects: Animals; Benzodiazepinones - pharmacology; Biological and medical sciences; CCK; Cholecystokinin; Cholecystokinin - administration & dosage; Cholecystokinin - pharmacology; Devazepide; Dose-Response Relationship, Drug; Food; Food intake; Fundamental and applied biological sciences. Psychology; Gastrointestinal; Gastrointestinal hormones; Hormone Antagonists - pharmacology; Injections, Intraperitoneal; Intestines - drug effects; Intestines - physiology; Intubation, Gastrointestinal; L-365,260; Male; Phenylurea Compounds; Rats; Rats, Sprague-Dawley; Receptors; Receptors, Cholecystokinin - antagonists & inhibitors; Receptors, Cholecystokinin - physiology; Satiety; Satiety Response - drug effects; Satiety Response - physiology; Sucrose - pharmacology; Vertebrates: digestive system; Receptors; Food intake; Satiety; L-365,260; CCK; Devazepide; Cholecystokinin; Gastrointestinal; Feeding behavior; Rat; Peptide hormone; Rodentia; Neuropeptide; Cholecystokinin receptor A; Vertebrata; Cholecystokinin receptor B; Gastrointestinal hormone; Mammalia; Animal; Nutrient
• ISSN: 0091-3057; 1873-5177
• DOI: 10.1016/0091-3057(95)02210-4

Previous work indicates that endogenous CCK mediates suppression of sham feeding by some intraintestinal nutrients. To test whether the mechanism involved is dependent upon action at type A or type B CCK receptors, we examined the ability of CCK A (devazepide) and CCK B (L-365,260) receptor antagonists to attenuate the suppression of sham feeding by intraintestinal oleic acid, maltotriose, or l-phenylalanine. Suppression by oleic acid or maltotriose was dose dependently attenuated by intraperitoneal administration of the CCK A receptor antagonist, as was suppression by exogenous CCK. The CCK B receptor antagonist failed to attenuate the suppression of sham feeding by these nutrients. Neither receptor antagonist attenuated the suppression of sham feeding induced by intraintestinal l-phenylalanine. These results suggest that suppression of sham feeding by intestinally infused oleic acid and maltotriose is mediated by endogenous CCK acting at CCK A receptors.