In vivo intracellular demonstration of an ischemia-induced postsynaptic potential from CA1 pyramidal neurons in rat hippocampus

Pyramidal neurons in the CA1 field of the hippocampus die a few days after transient cerebral ischemia.14.21 Excessive excitatory synaptic activation following reperfusion is thought to be responsible for such delayed cell death.4,24 However, it remains controversial whether excitatory synaptic tran...

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Bibliographic Details
Published inNeuroscience Vol. 75; no. 3; pp. 665 - 669
Main Authors Gao, T.M., Xu, Z.C.
Format Journal Article
LanguageEnglish
Published Oxford Elsevier Ltd 01.12.1996
Elsevier
Subjects
Animals
Biological and medical sciences
Brain Ischemia - physiopathology
excitotoxic
Hippocampus - physiopathology
intracellular recording
Male
Medical sciences
Neurology
neurophysiology
Pyramidal Cells - physiology
Rats
Rats, Wistar
synaptic transmission
Synaptic Transmission - physiology
transient cerebral ischemia
Vascular diseases and vascular malformations of the nervous system
transient cerebral ischemia
intracellular recording
AMPA
IPSP
EPSP
L-PSP
NMDA
synaptic transmission
neurophysiology
excitotoxic
Nervous system diseases
Rat
Rodentia
Central nervous system
Electrophysiology
Cardiovascular disease
Cerebral disorder
Vascular disease
In vivo
Vertebrata
Experimental disease
Mammalia
Ischemia
Cell death
Central nervous system disease
Postsynaptic potential
Pyramidal neuron
Cerebrovascular disease
Hippocampus
Brain (vertebrata)
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Summary:Pyramidal neurons in the CA1 field of the hippocampus die a few days after transient cerebral ischemia.14.21 Excessive excitatory synaptic activation following reperfusion is thought to be responsible for such delayed cell death.4,24 However, it remains controversial whether excitatory synaptic transmission in the CA1 field is increased following reperfusion.2,3,10,11,18,26 Here we report a novel postsynaptic potential evoked from CA1 pyramidal neurons preceding cell death after transient forebrain ischemia with intracellular recording and staining techniques in vivo. This result indicates the dramatic alteration of synaptic transmission in CA1 neurons after transient ischemia. The ischemia-induced postsynaptic potential may be associated with the postischemic neuronal injury.
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ISSN:0306-4522
1873-7544
DOI:10.1016/0306-4522(96)00411-3