Welder’s pulmonary hemosiderosis associated with systemic iron overload following exacerbation of acute adult T-cell leukemia/lymphoma

• Published in: Journal of Clinical and Experimental Hematopathology Vol. 57; no. 2; pp. 74 - 78
• Main Authors: Imoto, Naoto, Shiraki, Akira, Furukawa, Katsuya, Tange, Naoyuki, Murase, Atsushi, Hayakawa, Masaya, Iwata, Yosuke, Kosugi, Hiroshi
• Format: Journal Article
• Language: English
• Published: Japan The Japanese Society for Lymphoreticular Tissue Research 01.01.2017; JSLRT
• Subjects: Acute Disease; adult T-cell leukemia lymphoma; Case Study; Hemosiderosis - complications; Hemosiderosis - diagnosis; Hemosiderosis - pathology; Hemosiderosis, Pulmonary; Humans; Iron Overload - complications; Iron Overload - diagnosis; Iron Overload - pathology; Leukemia-Lymphoma, Adult T-Cell - pathology; Leukemia-Lymphoma, Adult T-Cell - therapy; Lung Diseases - complications; Lung Diseases - diagnosis; Lung Diseases - pathology; Male; Middle Aged; pulmonary hemosiderosis; systemic iron overload; welder’s lung; systemic iron overload; welder’s lung; pulmonary hemosiderosis; adult T-cell leukemia lymphoma
• ISSN: 1346-4280; 1880-9952
• DOI: 10.3960/jslrt.17024

Herein, we describe a 61-year-old man diagnosed with pulmonary hemosiderosis following chemotherapy for acute adult T-cell leukemia/lymphoma (ATLL). Liver and heart biopsy confirmed hemosiderosis. ATLL progressed, and the patient died from multiorgan damage. Welder’s lung may have been involved in hemosiderosis and systemic iron overload. Abnormal iron metabolism or immune reactions may have influenced the clinical course, but these were not validated. Detailed analyses of family medical and lifestyle histories, and genetic examination should be performed in cases of systemic iron overload.