The effect of rapid eye movement sleep deprivation on cortical beta-adrenergic receptors

The relationship between rapid eye movement sleep deprivation (REMD) and rat beta-adrenergic receptors was evaluated. REMD was achieved using the platform method and verified by EEG and EMG recordings. Although the amount of REM sleep was diminished 90%, there was no alteration in either the number...

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Bibliographic Details
Published inBrain research bulletin Vol. 11; no. 6; p. 729
Main Authors Abel, M S, Villegas, F, Abreu, J, Gimino, F, Steiner, S, Beer, B, Meyerson, L R
Format Journal Article
LanguageEnglish
Published United States 01.01.1983
Subjects
Animals
Cerebral Cortex - physiology
Dihydroalprenolol - metabolism
Kinetics
Male
Rats
Rats, Inbred Strains
Receptors, Adrenergic, beta - physiology
Sleep Deprivation
Sleep, REM - physiology
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Summary:The relationship between rapid eye movement sleep deprivation (REMD) and rat beta-adrenergic receptors was evaluated. REMD was achieved using the platform method and verified by EEG and EMG recordings. Although the amount of REM sleep was diminished 90%, there was no alteration in either the number of binding sites or their affinity for [3H]-dihydroalprenolol. Periods of stress as well as recovery periods after REMD were also without effect on the cortical beta-adrenergic receptors. Thus no support is garnered for the interaction of REMD and the cortical beta-adrenergic receptor binding parameters, although REMD is sometimes used as a mode of therapy for depression and other antidepressives do in fact affect the beta-adrenergic system. The mechanism of REMD as a potential antidepressive therapy is yet to be elucidated.
ISSN:0361-9230
DOI:10.1016/0361-9230(83)90015-1