The uptake of anionic and cationic amino acids by the isolated perfused sheep choroid plexus

The carrier-mediated uptake of anionic and cationic amino acids by the basolateral face (blood side) of the isolated perfused sheep choroid plexus was demonstrated using the paired-tracer dilution technique. The uptake of these two classes of amino acid was higher than at the blood-brain barrier wit...

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Bibliographic Details
Published inBrain research Vol. 581; no. 2; p. 351
Main Authors Preston, J E, Segal, M B
Format Journal Article
LanguageEnglish
Published Netherlands 29.05.1992
Subjects
Animals
Arginine - metabolism
Aspartic Acid - metabolism
Biological Transport - drug effects
Choroid Plexus - metabolism
Female
Glutamates - metabolism
Glutamates - pharmacology
In Vitro Techniques
Kinetics
Lysine - metabolism
Lysine - pharmacology
Male
Perfusion
Sheep
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Summary:The carrier-mediated uptake of anionic and cationic amino acids by the basolateral face (blood side) of the isolated perfused sheep choroid plexus was demonstrated using the paired-tracer dilution technique. The uptake of these two classes of amino acid was higher than at the blood-brain barrier with no cross-competition between them. In addition the uptake was markedly stereospecific with a high degree of selectivity and no interaction with the L-system amino acids.
ISSN:0006-8993
DOI:10.1016/0006-8993(92)90731-N