The effects of hyperosmolar agents lithium chloride and sucrose on the brain concentration of diminazene aceturate in rats

• Published in: Acta tropica Vol. 60; no. 2; pp. 119 - 125
• Main Authors: Odika, I.E., Asuzu, I.U., Anika, S.M.
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier B.V 01.10.1995; Elsevier
• Subjects: Animals; Antibiotics. Antiinfectious agents. Antiparasitic agents; Antiparasitic agents; Biological and medical sciences; Blood-Brain Barrier; Brain - metabolism; Diminazene - analogs & derivatives; Diminazene - pharmacokinetics; Diminazene aceturate; Female; Lithium chloride; Lithium Chloride - pharmacology; Male; Medical sciences; Permeability; Pharmacology. Drug treatments; Rats; Rats, Wistar; Sucrose; Sucrose - pharmacology; Tissue Distribution; Tropical medicine; Trypanocidal Agents - pharmacokinetics; Trypanosomiasis; Trypanosomiasis, African - drug therapy; Trypanosomiasis, African - metabolism; Nigeria; Africa; Blood-brain-barrier; Diminazene aceturate; Sucrose; Lithium chloride; Trypanosomiasis; Kinetoplastida; Protozoa; Rat; Rodentia; Lithium; Parasitosis; Permeability; Blood brain barrier; Intramuscular administration; Infection; Vertebrata; Chemotherapy; Mammalia; Animal; Parasiticid; Combined treatment; Pharmacokinetics; Trypanosoma brucei; Comparative study
• ISSN: 0001-706X; 1873-6254
• DOI: 10.1016/0001-706X(95)00098-Y

The concentrations of diminazene aceturate in the brain of Trypanosoma brucei brucei infected and uninfected rats treated with diminazene aceturate (3.1 mg/kg, im) and either LiCl (2.5, 5.0 and 10 μg/kg) or sucrose (0.25, 0.5 and 1.0 g/kg) were determined. When diminazene aceturate was administered at a standard dose of 3.1 mg/kg (im), the addition of LiCl (10 μg/kg, im) increased significantly ( P < 0.05) the concentration of the drug in the brains of both trypanosome infected and normal infected rats. The addition of sucrose (1.0 g/kg, im) instead of LiCl failed to give any significant increase in diminazene aceturate levels in the brain. The diminazene aceturate levels were significantly ( P < 0.05) higher in the organs (brain, kidney, liver and spleen) of trypanosome infected compared to uninfected rats. The concentration of diminazene aceturate in the organs increased significantly ( P < 0.05) with increasing concentrations of LiCl.