Complement depletion suppresses Lewis rat experimental allergic neuritis

Lewis rats immunized with myelin and complete Freund's adjuvant were treated with cobra venom factor (CVF) which depletes the C3 component of complement. CVF given at day 9 delayed the onset of experimental allergic neuritis (EAN) by 2-3 days and when given at days 9 and 12 delayed the onset of...

Full description

Saved in:
Bibliographic Details
Published inBrain research Vol. 419; no. 1-2; p. 97
Main Authors Feasby, T E, Gilbert, J J, Hahn, A F, Neilson, M
Format Journal Article
LanguageEnglish
Published Netherlands 01.09.1987
Subjects
Animals
Cobra Neurotoxin Proteins
Complement Activation - drug effects
Complement C3 - blood
Complement C3 - immunology
Freund's Adjuvant
Male
Neuritis, Autoimmune, Experimental - immunology
Neuritis, Autoimmune, Experimental - physiopathology
Rats
Rats, Inbred Lew
Spinal Nerve Roots - immunology
Spinal Nerve Roots - pathology
Time Factors
Online AccessGet more information

Cover

More Information
Summary:Lewis rats immunized with myelin and complete Freund's adjuvant were treated with cobra venom factor (CVF) which depletes the C3 component of complement. CVF given at day 9 delayed the onset of experimental allergic neuritis (EAN) by 2-3 days and when given at days 9 and 12 delayed the onset of EAN by 4-5 days. Lumbar nerve roots of CVF-treated rats had significantly less demyelination than those from control EAN rats.
ISSN:0006-8993
DOI:10.1016/0006-8993(87)90572-5