Evaluation of anti-diarrheal activity of Cleome viscosa L. extract in rats

• Published in: Phytomedicine (Stuttgart) Vol. 9; no. 8; pp. 739 - 742
• Main Authors: Parimala Devi, B., Boominathan, R., Mandal, S.C.
• Format: Journal Article
• Language: English
• Published: Germany Elsevier GmbH 01.12.2002; Urban & Fischer Verlag; Elsevier Science Ltd
• Subjects: Animals; anti-diarrheal; Antidiarrheals - administration & dosage; Antidiarrheals - pharmacology; Antidiarrheals - therapeutic use; Care and treatment; Castor Oil; Charcoal; Cleome; Cleome viscosa; CVME; Diarrhea - chemically induced; Diarrhea - prevention & control; Diarrhea in children; Dinoprostone; Dose-Response Relationship, Drug; entire plant; Female; Gastrointestinal Motility - drug effects; Male; Medicine, Botanic; Medicine, Herbal; methanol extract; Phytotherapy; Plant Extracts - administration & dosage; Plant Extracts - pharmacology; Plant Extracts - therapeutic use; Prevention; Rats; Rats, Wistar; India; Cleome viscosa; entire plant; CVME; methanol extract; anti-diarrheal
• ISSN: 0944-7113; 1618-095X
• DOI: 10.1078/094471102321621368

A study was undertaken to evaluate the effect of a methanol extract of the entire plant Cleome viscosa L. (CVME) (Family; Capparidaceae) for its anti-diarrheal potential against some of the experimental models of diarrhea in rats. CVME showed significant inhibitory activity against castor-oil-induced diarrhea and PGE 2- induced enteropooling in rats. The extract also showed a significant reduction in gastrointestinal motility in the charcoal meal test in rats. The results obtained establish the efficacy and substantiate the folklore claim as an anti- diarrheal agent.