Peroxisome proliferator-activated receptor γ ligand-induced growth inhibition of human hepatocellular carcinoma

Peroxisome proliferator-activated receptor gamma (PPARgamma) ligands have been implicated in the growth inhibition and differentiation of certain human cancers with diverse tissue origin. In this study, expression of PPARgamma in human hepatocellular carcinoma (HCC) and the effect of PPARgamma ligan...

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Published inBritish journal of cancer Vol. 84; no. 12; pp. 1640 - 1647
Main Authors RUMI, M. A. K, SATO, H, ISHIHARA, S, KAWASHIMA, K, HAMAMOTO, S, KAZUMORI, H, OKUYAMA, T, FUKUDA, R, NAGASUE, N, KINOSHITA, Y
Format Journal Article
LanguageEnglish
Published Basingstoke Nature Publishing Group 15.06.2001
Subjects
Biological and medical sciences
Carcinoma, Hepatocellular - pathology
Carcinoma, Hepatocellular - physiopathology
Cell Cycle - drug effects
Cell Differentiation
Cell Division
Dose-Response Relationship, Drug
Gastroenterology. Liver. Pancreas. Abdomen
Humans
Ligands
Liver Neoplasms - pathology
Liver Neoplasms - physiopathology
Liver. Biliary tract. Portal circulation. Exocrine pancreas
Medical sciences
Receptors, Cytoplasmic and Nuclear
Regular
Transcription Factors
Tumor Cells, Cultured
Tumors
Antineoplastic agent
Human
Cell proliferation
Agonist
Nuclear receptor
Gamma-Peptide chain
Ligand
Pioglitazone
Hepatic disease
Hepatocellular carcinoma
Malignant tumor
In vitro
Peroxisome proliferator
Cell cycle
Established cell line
Digestive diseases
Inhibition
Troglitazone
Biological receptor
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Summary:Peroxisome proliferator-activated receptor gamma (PPARgamma) ligands have been implicated in the growth inhibition and differentiation of certain human cancers with diverse tissue origin. In this study, expression of PPARgamma in human hepatocellular carcinoma (HCC) and the effect of PPARgamma ligands on HCC cells were investigated in vitro using Hep G2, HuH-7, KYN-1 and KYN-2 cell lines. All cell lines were found to express functionally active PPARgamma and a marked growth inhibition was induced by thiazolidinedione ligands troglitazone, and pioglitazone as well as with its natural ligand 15-deoxy-Delta(12,14)-prostaglandin J(2). The growth inhibitory effect was associated with a dose-dependent inhibition of DNA synthesis, cell cycle progression and alpha fetoprotein expression.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0007-0920
1532-1827
1532-1827
DOI:10.1054/bjoc.2001.1821