Determinant factors of postoperative recurrence of endometriosis: difference between endometrioma and pain

• Published in: European journal of obstetrics & gynecology and reproductive biology Vol. 205; pp. 54 - 59
• Main Authors: Tobiume, T, Kotani, Y, Takaya, H, Nakai, H, Tsuji, I, Suzuki, A, Mandai, M
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier B.V 01.10.2016
• Subjects: Adult; Age Factors; Determinant factors; Endometriosis; Endometriosis - diagnosis; Endometriosis - surgery; Female; Humans; Laparoscopy; Obstetrics and Gynecology; Ovarian Diseases - diagnosis; Ovarian Diseases - surgery; Pain; Pain - diagnosis; Postoperative hormonal treatment; Postoperative Period; Recurrence; Risk Factors; Treatment Outcome; Recurrence; Endometriosis; Pain; Determinant factors; Postoperative hormonal treatment
• ISSN: 0301-2115; 1872-7654
• DOI: 10.1016/j.ejogrb.2016.07.516

Abstract Objective Although the postoperative use of hormonal treatment for endometriosis is recommended in the European Society of Human Reproduction and Embryology guidelines to prevent the recurrence of endometriosis-associated dysmenorrhoea, hormonal treatment may not be necessary for all patients who undergo surgical treatment for endometriosis. The aim of this study was to clarify the determinant factors that predict the recurrence of endometriosis after surgery in order to develop personalized hormonal treatment recommendations. Factors associated with the recurrence of endometrioma and pain were investigated independently to identify the likelihood of recurrence in each individual patient. Study design Between 2008 and 2013, 352 patients underwent surgery and were diagnosed with endometriosis based on pathological findings at the study hospital. Among these patients, 191 experienced a recurrence of endometrioma in the absence of pre- or postoperative hormonal treatment. Various clinical factors such as pre-operative pain, intra-operative findings and postoperative improvement of pain were compared between patients who experienced recurrence after surgery and those who did not. Results The cumulative 5-year recurrence rate of endometrioma was 28.7% among the 191 patients who did not undergo pre- or postoperative hormonal treatment. Significant differences were detected in maximum tumour diameter, revised American Society for Reproductive Medicine score (r-ASRM score), operative time and operative blood loss between patients in the recurrent endometrioma group and the non-recurrent endometrioma group; only the r-ASRM score was significantly correlated with recurrence of endometrioma in the multivariate analysis. The cumulative 5-year rate of persistent/recurrent pain was 33.4%. There were significant differences in the postoperative improvement of pain between the persistent/recurrent pain group and the non-recurrent pain group according to the univariate and multivariate analyses. Conclusion This study suggests that the risk factors for recurrence of endometrioma differ from the risk factors for recurrence of pain. The use of postoperative hormonal treatment should be considered based on the dominant risk factors and needs of each patient.