Therapeutic Potential of Marine-Derived Cyclic Peptides as Antiparasitic Agents

Parasitic diseases still compromise human health. Some of the currently available therapeutic drugs have limitations considering their adverse effects, questionable efficacy, and long treatment, which have encouraged drug resistance. There is an urgent need to find new, safe, effective, and affordab...

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Published inMarine drugs Vol. 21; no. 12; p. 609
Main Authors Ribeiro, Ricardo, Costa, Lia, Pinto, Eugénia, Sousa, Emília, Fernandes, Carla
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 25.11.2023
Subjects
Antimalarial activity
antiparasitic activity
Antiparasitic agents
cyclic peptides
Drug development
Drug resistance
Drugs
leishmaniasis
malaria
marine resources
Parasites
Parasitic diseases
Parasitoses
Peptides
Protozoa
Tropical diseases
trypanosomiasis
cyclic peptides
trypanosomiasis
antiparasitic activity
leishmaniasis
malaria
marine resources
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Summary:Parasitic diseases still compromise human health. Some of the currently available therapeutic drugs have limitations considering their adverse effects, questionable efficacy, and long treatment, which have encouraged drug resistance. There is an urgent need to find new, safe, effective, and affordable antiparasitic drugs. Marine-derived cyclic peptides have been increasingly screened as candidates for developing new drugs. Therefore, in this review, a systematic analysis of the scientific literature was performed and 25 marine-derived cyclic peptides with antiparasitic activity ( - ) were found. Antimalarial activity is the most reported (51%), followed by antileishmanial (27%) and antitrypanosomal (20%) activities. Some compounds showed promising antiparasitic activity at the nM scale, being active against various parasites. The mechanisms of action and targets for some of the compounds have been investigated, revealing different strategies against parasites.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
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ObjectType-Review-1
ISSN:1660-3397
1660-3397
DOI:10.3390/md21120609