Fever of unknown origin in a 10-year-old boy with allergic rhinitis and asthma

We believe this case represents a clear example of drug fever, and it appears to be the first report to implicate ketotifen as the responsible agent, confirmed with double rechallenge. The recognition of drug fever is clinically important. Failure to recognize the etiologic relationship between the...

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Bibliographic Details
Published inAnnals of allergy, asthma, & immunology Vol. 85; no. 2; p. 102
Main Authors Caliskaner, A Z, Karaayvaz, M, Ozanguc, N
Format Journal Article
LanguageEnglish
Published United States 01.08.2000
Subjects
Asthma - complications
Child
Diagnosis, Differential
Drug Hypersensitivity - complications
Drug Hypersensitivity - diagnosis
Fever of Unknown Origin - etiology
Humans
Male
Rhinitis, Allergic, Perennial - complications
Rhinitis, Allergic, Seasonal - complications
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Summary:We believe this case represents a clear example of drug fever, and it appears to be the first report to implicate ketotifen as the responsible agent, confirmed with double rechallenge. The recognition of drug fever is clinically important. Failure to recognize the etiologic relationship between the drug and fever has unnecessary consequences, including extra testing, empiric therapy, and longer hospital stays. We suggest that ketotifen should be considered as a possible cause of fever in allergic patients receiving this drug.
ISSN:1081-1206
DOI:10.1016/S1081-1206(10)62447-7