Reversion by polyclonal antibodies of α effects of Tityus serrulatus venom on frog sciatic nerve
Fraction T 2 from Tityus serrulatus venom produced a marked lengthening of action potentials recorded with the single sucrose-gap technique, a characteristic effect of α scorpion toxins. This effect was not reversed by thorough washing of the nerve. On the other hand, T 2 fraction deactivated by com...
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Published in | Toxicology letters Vol. 76; no. 3; pp. 187 - 193 |
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Main Authors | , , |
Format | Journal Article |
Language | English |
Published |
Shannon
Elsevier Ireland Ltd
01.04.1995
Amsterdam Elsevier Science |
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Abstract | Fraction T
2 from
Tityus serrulatus venom produced a marked lengthening of action potentials recorded with the single sucrose-gap technique, a characteristic effect of α scorpion toxins. This effect was not reversed by thorough washing of the nerve. On the other hand, T
2 fraction deactivated by complete iodination did not cause any alteration of the compound action potential, even if applied in concentration as high as 4000 times the half saturation dose of the unmodified T
2 fraction. This high dose of deactivated T
2 did not hinder the onset of the full effect of a single dose of T
2 fraction applied subsequently. Polyclonal antibodies against native or against iodinated venom reverted the action of T
2 fraction, restoring normal electrical response. We conclude that both types of antibodies may remove the effect of α toxins on sodium channel. |
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AbstractList | Fraction T sub(2) from Tityus serrulatus venom produced a marked lengthening of action potentials recorded with the single sucrose-gap technique, a characteristic effect of alpha scorpion toxins. This effect was not reversed by thorough washing of the nerve. On the other hand, T sub(2) fraction deactivated by complete iodination did not cause any alteration of the compound action potential, even if applied in concentration as high as 4000 times the half saturation dose of the unmodified T sub(2) fraction. This high dose of deactivated T sub(2) did not hinder the onset of the full effect of a single dose of T sub(2) fraction applied subsequently. Polyclonal antibodies against native or against iodinated venom reverted the action of T sub(2) fraction, restoring normal electrical response. We conclude that both types of antibodies may remove the effect of alpha toxins on sodium channel. Fraction T2 from Tityus serrulatus venom produced a marked lengthening of action potentials recorded with the single sucrose-gap technique, a characteristic effect of alpha scorpion toxins. This effect was not reversed by thorough washing of the nerve. On the other hand, T2 fraction deactivated by complete iodination did not cause any alteration of the compound action potential, even if applied in concentration as high as 4000 times the half saturation dose of the unmodified T2 fraction. This high dose of deactivated T2 did not hinder the onset of the full effect of a single dose of T2 fraction applied subsequently. Polyclonal antibodies against native or against iodinated venom reverted the action of T2 fraction, restoring normal electrical response. We conclude that both types of antibodies may remove the effect of alpha toxins on sodium channel. Fraction T 2 from Tityus serrulatus venom produced a marked lengthening of action potentials recorded with the single sucrose-gap technique, a characteristic effect of α scorpion toxins. This effect was not reversed by thorough washing of the nerve. On the other hand, T 2 fraction deactivated by complete iodination did not cause any alteration of the compound action potential, even if applied in concentration as high as 4000 times the half saturation dose of the unmodified T 2 fraction. This high dose of deactivated T 2 did not hinder the onset of the full effect of a single dose of T 2 fraction applied subsequently. Polyclonal antibodies against native or against iodinated venom reverted the action of T 2 fraction, restoring normal electrical response. We conclude that both types of antibodies may remove the effect of α toxins on sodium channel. |
Author | Silveira, Josianne N. Heneine, Ibrahim F. Beirão, Paulo S.L. |
Author_xml | – sequence: 1 givenname: Josianne N. surname: Silveira fullname: Silveira, Josianne N. organization: Department of Biochemistry and Immunology, Institute of Biological Sciences — UFMG, Caixa Postal 486, 30.161-970 Belo Horizonte, MG, Brazil – sequence: 2 givenname: Ibrahim F. surname: Heneine fullname: Heneine, Ibrahim F. organization: Biophysics Laboratory, Department of Physiology and Biophysics, Institute of Biological Sciences — UFMG, Caixa Postal 486, 30.161-970 Belo Horizonte, MG, Brazil – sequence: 3 givenname: Paulo S.L. surname: Beirão fullname: Beirão, Paulo S.L. organization: Department of Biochemistry and Immunology, Institute of Biological Sciences — UFMG, Caixa Postal 486, 30.161-970 Belo Horizonte, MG, Brazil |
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Cites_doi | 10.1016/0161-5890(78)90070-6 10.1016/0264-410X(91)90012-U 10.1016/0041-0101(73)90119-0 10.1016/0041-0101(85)90288-0 10.1007/BF00586041 10.1016/S0021-9258(19)75272-7 10.1016/0041-0101(93)90122-Y 10.1111/j.1476-5381.1983.tb08812.x 10.1021/bi00369a052 10.1016/0041-0101(90)90411-Y 10.1016/0041-0101(93)90123-Z 10.1016/0041-0101(86)90082-6 10.1126/science.7100919 |
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Keywords | Sodium channel Scorpion venom Polyclonal antibody Toxin deactivation Scorpionides Nervous system diseases Frog Toxicity Amphibia Electrophysiology Animal origin Action potential Salientia Ionic channel In vitro Arachnida Vertebrata Treatment Arthropoda Animal Immunotherapy Venom Invertebrata Antidote Sciatic nerve |
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2 from
Tityus serrulatus venom produced a marked lengthening of action potentials recorded with the single sucrose-gap technique, a characteristic... Fraction T2 from Tityus serrulatus venom produced a marked lengthening of action potentials recorded with the single sucrose-gap technique, a characteristic... Fraction T sub(2) from Tityus serrulatus venom produced a marked lengthening of action potentials recorded with the single sucrose-gap technique, a... |
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SubjectTerms | Action Potentials - drug effects Animal poisons toxicology. Antivenoms Animals Biological and medical sciences Buthidae Electrophysiology Enzyme-Linked Immunosorbent Assay gamma-Globulins - immunology Immunoglobulin G - immunology In Vitro Techniques Medical sciences Neurotoxins - immunology Neurotoxins - toxicity Polyclonal antibody Rabbits Rana catesbeiana Sciatic Nerve - drug effects Scorpion venom Scorpion Venoms - immunology Scorpion Venoms - toxicity Scorpiones Sodium channel Sodium Channels - drug effects Tityus serrulatus Toxicology Toxin deactivation |
Title | Reversion by polyclonal antibodies of α effects of Tityus serrulatus venom on frog sciatic nerve |
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