Comparison of propafenone versus procainamide for the acute treatment of atrial fibrillation after cardiac surgery

A prospective, randomized, double-blind study to compare the efficacy in terminating postoperative atrial fibrillation of the class Ic drug propafenone versus class Ia drug procainamide was conducted. Intravenous propafenone was superior to procainamide in achieving rapid cardioversion and a better...

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Bibliographic Details
Published inThe American journal of cardiology Vol. 84; no. 3; pp. 345 - 347
Main Authors Geelen, Peter, O’Hara, Gilles E, Roy, Nathalie, Talajic, Mario, Roy, Denis, Plante, Sylvain, Turgeon, Jacques
Format Journal Article
LanguageEnglish
Published New York, NY Elsevier Inc 01.08.1999
Elsevier
Elsevier Limited
Subjects
Aged
Anti-Arrhythmia Agents - adverse effects
Anti-Arrhythmia Agents - therapeutic use
Antiarythmic agents
Atrial Fibrillation - drug therapy
Atrial Fibrillation - etiology
Atrial Fibrillation - physiopathology
Biological and medical sciences
Cardiac arrhythmia
Cardiac Surgical Procedures - adverse effects
Cardiology
Cardiovascular system
Coronary Artery Bypass - adverse effects
Double-Blind Method
Drug Administration Schedule
Drug therapy
Electrocardiography, Ambulatory
Female
Heart
Heart Rate - drug effects
Heart Valves - surgery
Humans
Hypotension - chemically induced
Infusions, Intravenous
Male
Medical sciences
Middle Aged
Pharmacology. Drug treatments
Procainamide - adverse effects
Procainamide - therapeutic use
Propafenone - adverse effects
Propafenone - therapeutic use
Surgery
Treatment Outcome
Heart
Human
Intensive cardiocirculatory care
Intravenous administration
Arrhythmia
Atrial fibrillation
Procainamide
Instrumentation therapy
Cardiovascular disease
Cardioversion
Antiarrhythmic agent
Excitability disorder
Chemotherapy
Treatment
Heart disease
Surgery
Complication
Propafenone
Comparative study
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Summary:A prospective, randomized, double-blind study to compare the efficacy in terminating postoperative atrial fibrillation of the class Ic drug propafenone versus class Ia drug procainamide was conducted. Intravenous propafenone was superior to procainamide in achieving rapid cardioversion and a better rate control with a lower incidence of symptomatic hypotension.
ISSN:0002-9149
1879-1913
DOI:10.1016/S0002-9149(99)00292-1