Acute lymphoblastic leukemia of NK-cell lineage: Responses to IL-2

Acute lymphoblastic leukemias with phenotypic characteristics of natural killer cell derived lineage are extremely uncommon. We identified an ALL with a phenotype consistent with an NK-cell of origin. The blasts underwent a proliferative response to r-IL2 in culture but showed no spontaneous or r-IL...

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Published inLeukemia research Vol. 13; no. 9; pp. 735 - 743
Main Authors Pirruccello, Samuel J., Bicak, Molly S., Gordon, Bruce G., Gajl-Peczalska, Kazimiera, Gnarra, David J., Coccia, Peter F.
Format Journal Article
LanguageEnglish
Published Oxford Elsevier Ltd 1989
Elsevier Science
Subjects
Acute lymphoblastic leukemia
Adolescent
Antigens, CD - analysis
Biological and medical sciences
Blood and lymphatic vessels
Bone Marrow - immunology
Bone Marrow - pathology
Cardiology. Vascular system
CD11b
CD8
Cell Division - drug effects
Cytotoxicity, Immunologic
Humans
Immunity, Cellular
interleukin 2
Interleukin-2 - pharmacology
Killer Cells, Natural - immunology
Killer Cells, Natural - pathology
Lymphocyte Activation - drug effects
Male
Medical sciences
natural killer cell
phenotype
Precursor Cell Lymphoblastic Leukemia-Lymphoma - immunology
Precursor Cell Lymphoblastic Leukemia-Lymphoma - pathology
ALL
γINF
DNM
DMSO
TdT
r-IL2
UNMC
CD11b
MTX
FITC
interleukin 2
UMCH
natural killer cell
CR 3
phenotype
CD
AC
Fc R
LGL
Acute lymphoblastic leukemia
PE
lu 50
CD8
FCS
FB
NK
Natural killer cell
Human
Immunohistochemistry
Cell culture
Phenotype
Interleukin 2
Stimulation
Hemopathy
Acute lymphocytic leukemia
Large granular lymphocyte
Tumor cell
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Summary:Acute lymphoblastic leukemias with phenotypic characteristics of natural killer cell derived lineage are extremely uncommon. We identified an ALL with a phenotype consistent with an NK-cell of origin. The blasts underwent a proliferative response to r-IL2 in culture but showed no spontaneous or r-IL2 or γ-INF induced cytotoxicity. With r-IL2 stimulation however, the tumor cells demonstrated a dramatic acquisition of low density CD8 surface positivity and a loss of CD11b expression after short term culture. By comparison to ALL of B or T lineage, NK ALL likely represents an early stage of bone marrow derived NK-cell precursor.
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ISSN:0145-2126
1873-5835
DOI:10.1016/0145-2126(89)90086-6