Distinct Requirements for Interleukin-6 in Airway Inflammation Induced by Diesel Exhaust in Mice

To clarify the possible role of interleukin-6 in aggravation of inflammatory responses in diesel exhaust-exposed mice, we compared the infiltration of inflammatory cells and the production of chemokines between interleukin-6-deficient and wild-type mice following 0, 1.0, or 3.0 mg diesel particles/m...

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Bibliographic Details
Published inImmunopharmacology and immunotoxicology Vol. 28; no. 4; pp. 703 - 714
Main Authors Fujimaki, Hidekazu, Kurokawa, Yoshika, Yamamoto, Shoji, Satoh, Masahiko
Format Journal Article
LanguageEnglish
Published England Informa UK Ltd 2006
Subjects
Animals
Bronchoalveolar Lavage Fluid - cytology
Cells, Cultured
Chemokines - biosynthesis
Chemokines, CXC
Cytokines - biosynthesis
Inflammation - metabolism
Inflammation - pathology
Interleukin-6 - genetics
Interleukin-6 - physiology
Male
Mice
Mice, Knockout
Respiratory Tract Diseases - pathology
Vehicle Emissions - toxicity
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Summary:To clarify the possible role of interleukin-6 in aggravation of inflammatory responses in diesel exhaust-exposed mice, we compared the infiltration of inflammatory cells and the production of chemokines between interleukin-6-deficient and wild-type mice following 0, 1.0, or 3.0 mg diesel particles/m3 diesel exhaust inhalation for 4 weeks. Exposure to diesel exhaust significantly increased the number of inflammatory cells and the amount of CCL17 and CXCL3 in bronchoalveolar lavage fluids from wild-type mice, but not in interleukin-6-deficient mice. These findings suggest that interleukin-6 plays a critical role in airway inflammatory responses induced by diesel exhaust inhalation.
ISSN:0892-3973
1532-2513
DOI:10.1080/08923970601067433