MMP-9 microsatellite polymorphism: Association with the progression of intima-media thickening and constrictive remodeling of carotid atherosclerotic plaques
Intima-media thickening (IMT) of carotid arteries and constrictive remodeling (CR) of atherosclerotic plaques are vascular pathologic characteristics that precede the onset of vascular events. SMC migration and proliferation are linked both to IMT and CR and are matrix metalloproteinase 9 (MMP-9) de...
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Published in | Atherosclerosis Vol. 182; no. 2; pp. 287 - 292 |
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Main Authors | , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Amsterdam
Elsevier Ireland Ltd
01.10.2005
Elsevier |
Subjects | |
Online Access | Get full text |
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Summary: | Intima-media thickening (IMT) of carotid arteries and constrictive remodeling (CR) of atherosclerotic plaques are vascular pathologic characteristics that precede the onset of vascular events. SMC migration and proliferation are linked both to IMT and CR and are matrix metalloproteinase 9 (MMP-9) dependent. A genetic polymorphism (PM) of
MMP-9, a CA (13–27) microsatellite in the promoter region, which accounts for differential expression of MMP-9, could be linked to progression of IMT and CR.
Progression of IMT and CR of plaques in carotid arteries were studied in 55 consecutive patients with a 12–18 months follow-up. All patients were genotyped for
MMP-9 PM. A positive linear relationship between the number of repeats and the progression of IMT (
P
=
0.028) as well as of CR (
P
=
0.018) was found. The analogous relationship was obtained when only the allele with longer microsatellite was considered.
Carriers of more than 20 repeats in one allele showed faster both IMT growth (
P
=
0.045) and stenosis progressions of plaques (
P
=
0.019). In multivariate analysis, age, dyslipidemia, and
MMP-9 PM were determinants of IMT progression, while
MMP-9 PM was the only one of CR.
In conclusion, the high number of CA repeats in MMP-9 promoter is positively correlated with faster IMT and CR progression. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 0021-9150 1879-1484 |
DOI: | 10.1016/j.atherosclerosis.2005.01.009 |