A study on the effect of lesions of area 7 of the parietal cortex on the short-term visual spatial memory of rhesus monkeys ( Macaca mulatta)

• Published in: Brain research Vol. 600; no. 2; pp. 187 - 192
• Main Authors: Pu, Xiaochun, Ma, Yuanye, Cai, Jingxia
• Format: Journal Article
• Language: English
• Published: London Elsevier B.V 15.01.1993; Amsterdam Elsevier; New York, NY
• Subjects: Anatomical correlates of behavior; Animals; Behavioral psychophysiology; Biological and medical sciences; Cerebral Cortex - pathology; Cerebral Cortex - physiology; Direct delayed response task; Electrophysiology; Evoked Potentials, Visual - physiology; Fundamental and applied biological sciences. Psychology; Lesion; Macaca mulatta; Male; Memory - physiology; Movement Disorders - pathology; Movement Disorders - physiopathology; Parietal cortex; Parietal Lobe - physiology; Prefrontal cortex; Psychology. Psychoanalysis. Psychiatry; Psychology. Psychophysiology; Rhesus monkey ( Macaca mulatta); Short-term visual spatial memory; Space life sciences; Space Perception - physiology; Visual Perception - physiology; Direct delayed response task; Rhesus monkey ( Macaca mulatta); Prefrontal cortex; Lesion; Short-term visual spatial memory; Parietal cortex; Memory; Central nervous system; Monkey; Macaca mulatta; Space perception; Vertebrata; Mammalia; Animal; Primates; Simioidea; Brain (vertebrata)
• ISSN: 0006-8993; 1872-6240
• DOI: 10.1016/0006-8993(93)91372-Y

This research is focused on the contribution of area 7 to the short-term visual spatial memory. Three rhesus monkeys ( Macaca mulatta) were trained in the direct delayed response task in which 5 delay intervals were used in each session. When each monkey reached the criterion of 90% correct responses in 5 successive sessions, two monkeys underwent a surgery while the other one received a sham operation as a control. In the first stage of the surgery, bilateral areas 7a, 7b and 7ip of the parietal cortex of two monkeys were precisely lesioned. After 7 days of recuperation, the monkeys were required to do the same task. The average percentage of correct responses in the lesioned animals decreased from 94.7% to 89.3% and 93.3% to 82.0% respectively (no significance, P > 0.05, n = 2). In addition, the monkeys' complex movements were mildly impaired. The lesioned monkeys were found to have difficulty picking up food from the wells. In the second stage, bilateral area 7m was lesioned. In the 5 postoperative sessions, the average percentage of correct responses in one monkey, with a relatively precise 7m lesion, decreased from 94.7% to 92.2% (no significance, P > 0.05). while the other monkey, with widely spread necrosis of lateral parietal cortex, showed an obvious decline in performance, but still over the chance level. After 240 trials this monkey reattained the normal criterion. The results of this research suggest that the lesions of area 7 of the parietal cortex did not significantly affect the short-term visual spatial memory, which has been shown to be sensitive to lesions of the prefrontal cortex; they also support the notion of dissociation of spatial functions in the prefrontal and parietal cortices.