Development and comprehensive evaluation of a noninvasive prenatal paternity testing method through a scaled trial

Highlights•We developed a noninvasive prenatal paternity testing (NIPPT) method based on target sequencing strategy. •For the first time, we systemically evaluate the efficiency, reliability and sensitivity of NIPPT through a scaled trial. •Our results suggest that NIPPT can accurately determine pat...

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Bibliographic Details
Published inForensic science international : genetics Vol. 43; p. 102158
Main Authors Chang, Liao, Yu, Huiyun, Miao, Xinyao, Zhang, Jianbo, Li, Shengbin
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier B.V 01.11.2019
Subjects
Case-Control Studies
Cell-free DNA
Cell-Free Nucleic Acids - genetics
Early pregnancy
Female
Genotype
Gestational Age
High-Throughput Nucleotide Sequencing
Humans
Large scale trial
Male
Massive parallel sequencing
Microsatellite Repeats
Non-invasive prenatal paternity testing
Noninvasive Prenatal Testing - methods
Paternity
Pathology
Polymorphism, Single Nucleotide
Pregnancy
Reproducibility of Results
Cell-free DNA
Large scale trial
Early pregnancy
Non-invasive prenatal paternity testing
Massive parallel sequencing
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Summary:Highlights•We developed a noninvasive prenatal paternity testing (NIPPT) method based on target sequencing strategy. •For the first time, we systemically evaluate the efficiency, reliability and sensitivity of NIPPT through a scaled trial. •Our results suggest that NIPPT can accurately determine paternity from 6 weeks after conception until born. •The fetal DNA fraction increased rapidly at the last trimester until delivery but moderately at the second trimester.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:1872-4973
1878-0326
DOI:10.1016/j.fsigen.2019.102158