EFFECT OF SODIUM NITROPRUSSIDE-INDUCED HYPOTENSION ON PULMONARY DEADSPACE

Deliberate hypotension with nitroprusside produced a 40% reduction in mean arterial pressure, but it did not cause any change in the pulmonary deadspace to tidal volume ratio (VD/VT). This was achieved by adequate hydration both before and during hypotension, as indicated by constant filling pressur...

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Bibliographic Details
Published inBritish journal of anaesthesia : BJA Vol. 54; no. 11; pp. 1197 - 1200
Main Authors KHAMBATTA, H.J., STONE, J.G., MATTEO, R.S.
Format Journal Article
LanguageEnglish
Published England Elsevier Ltd 01.11.1982
Oxford University Press
Subjects
Adult
Ferricyanides - pharmacology
Hemodynamics - drug effects
Humans
Hypotension, Controlled
Laminectomy
Male
Nitroprusside - pharmacology
Respiratory Dead Space - drug effects
Spinal Fusion
Tidal Volume
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Summary:Deliberate hypotension with nitroprusside produced a 40% reduction in mean arterial pressure, but it did not cause any change in the pulmonary deadspace to tidal volume ratio (VD/VT). This was achieved by adequate hydration both before and during hypotension, as indicated by constant filling pressures. Thus we have shown that deliberate hypotension per se does not increase VD/VT, and that vasodilataaon may bring about a relatively hypovolaemic state and be responsible for the increase in VD/VT observed by previous workers
Bibliography:istex:E157BAA4A1B40C3203BAFA414672CF1868160966
ark:/67375/HXZ-6FJJSP09-D
ArticleID:54.11.1197
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0007-0912
1471-6771
DOI:10.1093/bja/54.11.1197