Mycoplasma genitalium Prevalence, Coinfection, and Macrolide Antibiotic Resistance Frequency in a Multicenter Clinical Study Cohort in the United States

• Published in: Journal of clinical microbiology Vol. 54; no. 9; pp. 2278 - 2283
• Main Authors: Getman, Damon, Jiang, Alice, O'Donnell, Meghan, Cohen, Seth
• Format: Journal Article
• Language: English
• Published: United States American Society for Microbiology 01.09.2016
• Subjects: Adolescent; Adult; Aged; Anti-Bacterial Agents - pharmacology; Chlamydia trachomatis; Coinfection - epidemiology; Coinfection - microbiology; Drug Resistance, Bacterial; Epidemiology; Female; Humans; Macrolides - pharmacology; Male; Middle Aged; Mycoplasma genitalium; Mycoplasma genitalium - drug effects; Mycoplasma genitalium - isolation & purification; Mycoplasma Infections - epidemiology; Mycoplasma Infections - microbiology; Neisseria gonorrhoeae; Prevalence; Risk Factors; Trichomonas vaginalis; United States - epidemiology; Young Adult; United States
• ISSN: 0095-1137; 1098-660X; 1098-660X
• DOI: 10.1128/JCM.01053-16

The prevalence rates of Mycoplasma genitalium infections and coinfections with other sexually transmitted organisms and the frequency of a macrolide antibiotic resistance phenotype were determined in urogenital specimens collected from female and male subjects enrolled in a multicenter clinical study in the United States. Specimens from 946 subjects seeking care from seven geographically diverse clinical sites were tested for M. genitalium and for Chlamydia trachomatis , Neisseria gonorrhoeae , and Trichomonas vaginalis . Sequencing was used to assess macrolide antibiotic resistance among M. genitalium -positive subjects. M. genitalium prevalence rates were 16.1% for females and 17.2% for males. Significant risk factors for M. genitalium infections were black race, younger age, non-Hispanic ethnicity, and female symptomatic status. Female M. genitalium infections were significantly more prevalent than C. trachomatis and N. gonorrhoeae infections, while the M. genitalium infection rate in males was significantly higher than the N. gonorrhoeae and T. vaginalis infection rates. The macrolide-resistant phenotype was found in 50.8% of females and 42% of males. These results show a high prevalence of M. genitalium single infections, a lower prevalence of coinfections with other sexually transmitted organisms, and high rates of macrolide antibiotic resistance in a diverse sample of subjects seeking care across a wide geographic area of the United States.