Modelling hemodynamic response function in epilepsy

Highlights • We investigated the impact of a subject-specific hemodynamic response function (HRF) to describe the hemodynamic differences in fMRI data analysis across epileptic patients versus the use of a standard model. • Simulations assess how the use of different HRF models affect the results of...

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Bibliographic Details
Published inClinical neurophysiology Vol. 124; no. 11; pp. 2108 - 2118
Main Authors Storti, S.F, Formaggio, E, Bertoldo, A, Manganotti, P, Fiaschi, A, Toffolo, G.M
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier Ireland Ltd 01.11.2013
Subjects
Adult
Brain - physiopathology
Brain Mapping
Cerebrovascular Circulation
Drug-resistant epilepsy
EEG–fMRI
Electroencephalography
Epilepsy - diagnosis
Epilepsy - physiopathology
Female
Hemodynamic response function
Hemodynamics
Humans
Individual-based HRF
Magnetic Resonance Imaging
Male
Models, Cardiovascular
Neurology
EEG–fMRI
Individual-based HRF
Drug-resistant epilepsy
Hemodynamic response function
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Summary:Highlights • We investigated the impact of a subject-specific hemodynamic response function (HRF) to describe the hemodynamic differences in fMRI data analysis across epileptic patients versus the use of a standard model. • Simulations assess how the use of different HRF models affect the results of the statistical analysis and suggest the importance of using an individual-based HRF model. • The individual-based HRF model parsimoniously describes the fMRI time course for epileptic patients and possibly provides reliable BOLD activation maps.
Bibliography:ObjectType-Case Study-2
SourceType-Scholarly Journals-1
ObjectType-Feature-4
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ObjectType-Report-1
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ISSN:1388-2457
1872-8952
DOI:10.1016/j.clinph.2013.05.024