Adapting Protocols or Models for Use in Insulin-Requiring Diabetes and Islet Transplant Recipients

The authors' perspective is described regarding modifications made in their clinic to glucose challenge protocols and mathematical models in order to estimate insulin secretion, insulin sensitivity and glucose effectiveness in patients living with Insulin-Requiring Diabetes and patients who rec...

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Published inFrontiers in endocrinology (Lausanne) Vol. 12; p. 611512
Main Authors Ward, Glenn M, Walters, Jacqueline M, Gooley, Judith L, Boston, Raymond C
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 16.07.2021
Subjects
Diabetes Mellitus, Type 1 - therapy
Endocrinology
Humans
Insulin Resistance
Insulin Secretion
insulin sensitivity
islet transplantation
Islets of Langerhans Transplantation
mathematical modeling
minimal model
Models, Biological
Transplant Recipients
type 1 diabetes mellitus
insulin sensitivity
type 1 diabetes mellitus
C-peptide model
mathematical modeling
islet transplantation
minimal model
insulin secretion
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Summary:The authors' perspective is described regarding modifications made in their clinic to glucose challenge protocols and mathematical models in order to estimate insulin secretion, insulin sensitivity and glucose effectiveness in patients living with Insulin-Requiring Diabetes and patients who received Pancreatic Islet Transplants to treat Type I diabetes (T1D) with Impaired Awareness of Hypoglycemia. The evolutions are described of protocols and models for use in T1D, and Insulin-Requiring Type 2 Diabetes (T2D) that were the basis for studies in the Islet Recipients. In each group, the need for modifications, and how the protocols and models were adapted is discussed. How the ongoing application of the adaptations is clarifying the Islet pathophysiology in the Islet Transplant Recipients is outlined.
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This article was submitted to Systems Endocrinology, a section of the journal Frontiers in Endocrinology
Edited by: Susanna Röblitz, University of Bergen, Norway
Reviewed by: Kyle C. A. Wedgwood, University of Exeter, United Kingdom; Thomas Linn, University of Giessen, Germany
ISSN:1664-2392
1664-2392
DOI:10.3389/fendo.2021.611512