Circulating ICAM-1, VCAM-1, E-Selectin, P-Selectin, and TNFRII in Patients with Coronary Artery Disease

• Published in: Immunological investigations Vol. 33; no. 3; pp. 263 - 275
• Main Authors: Hajilooi, M., Sanati, A., Ahmadieh, A., Ghofraniha, A., Massoud, Ahmad
• Format: Journal Article
• Language: English
• Published: England Informa UK Ltd 01.01.2004; Taylor & Francis
• Subjects: Adhesion molecules; Adult; Aged; Atherosclerosis; Cell Adhesion Molecules - blood; Coronary artery disease; Coronary Artery Disease - physiopathology; Coronary heart disease; Coronary Stenosis - physiopathology; E-Selectin - blood; Female; Humans; Intercellular Adhesion Molecule-1 - blood; Iran; Logistic Models; Male; Middle Aged; P-Selectin - blood; Receptors, Tumor Necrosis Factor, Type II - blood; Risk Factors; Tumor necrosis factor receptor 2; Vascular Cell Adhesion Molecule-1 - blood; Iran; Iran, Tehran
• ISSN: 0882-0139; 1532-4311
• DOI: 10.1081/IMM-120037275

Objective: To evaluate the relationship between the serum concentration of tumor necrosis factor receptor 2 (TNFRII) and some adhesion molecules [including intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1), P-Selectin, and E-Selectin] and coronary artery stenosis. Design and setting: Observational (cross-sectional) study in a University Heart Hospital in Tehran, Iran. Patients: 75 patients with angiographically proven coronary artery disease were compared with 81 individuals who had undergone coronary angiography with no significant evidence of stenosis (control subjects). Methods: Soluble adhesion molecules and TNFRII were determined by enzyme-linked immunosorbent assay technique. sICAM-1 and sP-selectin values were significantly higher in patients with coronary artery disease than in control subjects [146(38) vs. 132(48) p < 0.04 and 275(107) vs. 241(104) ng ml p < 0.04 respectively]. Multiple logistic regression analysis showed sICAM-1 an independent discriminating risk factor for coronary artery disease (p < 0.03). Prediction models that incorporated sICAM-1 in addition to other established coronary risk factors were significantly better at predicting risk than the models based on the other risk factors alone. Multiple regression analysis indicated that sP-selectin levels were greater in patients with single-vessel disease than in the respective normal (p < 0.01). Conclusions: Our findings suggest that sICAM-1 has an association with s1 coronary artery disease as such; the evaluation of this marker may improve the coronary risk assessment in Iranian patients.