Management of idiopathic membranous nephropathy

Idiopathic membranous nephropathy (IMN) can have a variable natural course. Treatments able to induce remission can improve the long-term prognosis. However, the optimal therapy for IMN remains controversial. We reviewed the historical and current literature from 1979 to 2010 regarding the natural c...

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Bibliographic Details
Published inExpert opinion on pharmacotherapy Vol. 11; no. 13; p. 2163
Main Authors Ponticelli, Claudio, Passerini, Patrizia
Format Journal Article
LanguageEnglish
Published England 01.09.2010
Subjects
Aged
Aged, 80 and over
Female
Glomerulonephritis, Membranous - drug therapy
Glomerulonephritis, Membranous - pathology
Glomerulonephritis, Membranous - physiopathology
Humans
Male
Nephrotic Syndrome - drug therapy
Nephrotic Syndrome - pathology
Prognosis
Randomized Controlled Trials as Topic
Treatment Outcome
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Summary:Idiopathic membranous nephropathy (IMN) can have a variable natural course. Treatments able to induce remission can improve the long-term prognosis. However, the optimal therapy for IMN remains controversial. We reviewed the historical and current literature from 1979 to 2010 regarding the natural course of IMN and the possible treatments giving special emphasis to randomized controlled trials and to more recent approaches. The reader will gain a comprehensive review of the available treatments of IMN. A personal therapeutic algorithm for nephrotic patients with IMN is also provided. At least five different treatments showed efficacy in many (but not all) patients with IMN.
ISSN:1744-7666
DOI:10.1517/14656566.2010.494599