The combined treatment of human peripheral blood mononuclear cells with thymolymphotropin and interleukin 2 increases PPD-driven T-cell proliferation and IL-2 induced cellular cytotoxicity against HIV-infected cells

Two in vitro systems (the DNA synthetic response to mycobacterial antigens and cytotoxicity against lymphoid cells) were used to analyse the effect of thymolymphotropin (TLT) on peripheral blood mononuclear cells (PBMC). Purified protein derivative of mycobacteria (PPD)-driven T-cell proliferation i...

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Published inInternational journal of immunopharmacology Vol. 13; no. 8; p. 1157
Main Authors Di Massimo, A M, Gilardini Montani, M S, Gilardini, M S, Bardone, M R, Moras, M L, Malkovsky, M, Antonelli, G, Colizzi, V
Format Journal Article
LanguageEnglish
Published England 1991
Subjects
Cytotoxicity, Immunologic
HIV - physiology
HIV Infections - immunology
HIV Infections - therapy
Humans
Immunotherapy
In Vitro Techniques
Interleukin-2 - administration & dosage
Leukocytes, Mononuclear - immunology
Lymphocyte Activation
T-Lymphocytes - immunology
Thymus Extracts - administration & dosage
Tuberculin - immunology
Virus Replication
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Summary:Two in vitro systems (the DNA synthetic response to mycobacterial antigens and cytotoxicity against lymphoid cells) were used to analyse the effect of thymolymphotropin (TLT) on peripheral blood mononuclear cells (PBMC). Purified protein derivative of mycobacteria (PPD)-driven T-cell proliferation in low-responder donors was increased by the combined treatment with TLT and suboptimal doses of recombinant interleukin 2 (IL-2). Similarly, the activities of natural killer (NK) cells and lymphokine-activated killer (LAK) cells have been enhanced in PBMC cultures pretreated with TLT. Also, TLT showed an enhancing effect on the development of LAK cells capable of lysing Epstein-Barr virus (EBV)-transformed B-lymphocytes infected or uninfected with the human immunodeficiency virus (HIV).
ISSN:0192-0561
DOI:10.1016/0192-0561(91)90167-6