Conventional Cisplatin-Based Combination Chemotherapy Is Effective in the Treatment of Metastatic Spermatocytic Seminoma with Extensive Rhabdomyosarcomatous Transformation

• Published in: Cancer research and treatment Vol. 47; no. 4; pp. 931 - 936
• Main Authors: Jeong, Yumun, Cheon, Jaekyung, Kim, Tae-Oh, Lim, Doo-Ho, Lee, Sunpyo, Cho, Young-Mi, Hong, Jun Hyuk, Lee, Jae Lyun
• Format: Journal Article
• Language: English
• Published: Korea (South) Korean Cancer Association 01.10.2015; 대한암학회
• Subjects: Antineoplastic Agents - administration & dosage; Antineoplastic Agents - therapeutic use; Antineoplastic Combined Chemotherapy Protocols - therapeutic use; Case Report; Cisplatin - administration & dosage; Cisplatin - therapeutic use; Etoposide - administration & dosage; Etoposide - therapeutic use; Humans; Ifosfamide - administration & dosage; Ifosfamide - therapeutic use; Male; Middle Aged; Seminoma - drug therapy; Testicular Neoplasms - drug therapy; 의약학; Drug therapy; Radiotherapy; Seminoma
• ISSN: 1598-2998; 2005-9256; 2005-9256
• DOI: 10.4143/crt.2014.049

A 52-year-old man was presented with a huge left testicular mass and palpable cervical lymphadenopathy with retroperitoneal lymph node enlargement on an abdominal computed tomography. A left radical orchiectomy and an ultrasound-guided neck node biopsy were performed. A pathological examination revealed spermatocytic seminoma with extensive rhabdomyosarcomatous transformation, a condition known to be highly resistant to platinum-based chemotherapy. The patient received four cycles of etoposide, ifosfamide and cisplatin (VIP) chemotherapy. A repeat computed tomography revealed a substantial regression consistent with a partial response. Retroperitoneal lymph node dissection was attempted, which revealed rhabdomyosarcoma; however, complete microscopic resection was not achieved. After surgery, the residual abdominal lymph node progressed and salvage paclitaxel, ifosfamide and cisplatin (TIP) chemotherapy was employed, which again achieved a partial response. Here, we present a first case report of a spermatocytic seminoma with extensive rhabdomyosarcomatous transformation and multiple metastatic lymphadenopathies that showed a favorable response to platinum-based systemic chemotherapy.