The chemotactic effect of Phlebotomus duboscqi (diptera: psychodidae) salivary gland lysates to murine monocytes

• Published in: Acta tropica Vol. 60; no. 2; pp. 97 - 100
• Main Authors: Anjili, C.O., Mbati, P.A., Mwangi, R.W., Githure, J.I., Olobo, J.O., Robert, L.L., Koech, D.K.
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier B.V 01.10.1995; Elsevier
• Subjects: Animals; BALB/c; Biological and medical sciences; Chemotaxis; Chemotaxis, Leukocyte; Female; Human protozoal diseases; Infectious diseases; Insect Vectors - physiology; Leishmania - immunology; Leshmaniasis; Macrophages - immunology; Medical sciences; Mice; Mice, Inbred BALB C; Monocyte; Monocytes - immunology; Parasitic diseases; Phlebotomus duboscqi; Protozoal diseases; Psychodidae - parasitology; Psychodidae - physiology; Salivary gland lysate; Salivary Glands - physiology; Tropical medicine; Africa; Phlebotomus duboscqi; Salivary gland lysate; Monocyte; Chemotaxis; BALB/c; Protozoal disease; Pathogenesis; Insecta; Rodentia; Psychodidae; Salivary gland; Parasitosis; Leishmaniasis; In vitro; Infection; Vertebrata; Mammalia; Phlebotomus; Mouse; Arthropoda; Animal; Invertebrata; Diptera
• ISSN: 0001-706X; 1873-6254
• DOI: 10.1016/0001-706X(95)00112-R

The possibility that salivary gland lysates of Phlebotomus duboscqi are able to attract vertebrate monocytes was investigated. In vitro studies showed that salivary gland lysates of P. duboscqi, the vector of Leishmania major in Kenya, are chemotactic to mouse peritoneal monocytes. This attraction of monocytes by vector salivary gland lysates may form part of the mechanisms through which sandfly saliva ensures successful parasitization of macrophages in a susceptible host by Leishmania parasites.