Sequence of a cDNA encoding the p53 protein in Rhesus monkey ( Macaca mulatta)

• Published in: Gene Vol. 138; no. 1; pp. 223 - 226
• Main Authors: David Kay, H., Mountjoy, Charles P., Wu, Guanqing, Cornish, Kurtis G., Smith, Larry J.
• Format: Journal Article
• Language: English
• Published: Lausanne Elsevier B.V 28.01.1994; Amsterdam Elsevier; New York, NY
• Subjects: Amino Acid Sequence; AML; animal model; Animals; antisense; Base Sequence; Biological and medical sciences; cancer; Consensus Sequence; DNA Primers; DNA, Complementary - chemistry; Exons; Fundamental and applied biological sciences. Psychology; Genes, p53; Genes. Genome; Hominidae - genetics; Humans; leukemia; Macaca mulatta; Macaca mulatta - genetics; Molecular and cellular biology; Molecular genetics; Molecular Sequence Data; PCR; Polymerase Chain Reaction; Sequence Homology, Amino Acid; therapeutics; Tumor Suppressor Protein p53 - biosynthesis; Tumor Suppressor Protein p53 - genetics; AML; aa; leukemia; therapeutics; ORF; nt; bp; p53; kb; cancer; cDNA; oligo; animal model; AS oligo; PCR; antisense; Human; Nucleotide sequence; Sequence alignment; Homology; Macaca mulatta; Vertebrata; Mammalia; Complementary DNA; Primates; Simioidea; Aminoacid sequence; Structural analysis; Tumor suppressor gene
• ISSN: 0378-1119; 1879-0038
• DOI: 10.1016/0378-1119(94)90812-5

A 2184-nucleotide (nt) sequence of the p53 gene in Rhesus monkey ( Macaca mulatta) was determined in order to facilitate the use of the Rhesus as an animal model in the testing of novel antisense oligodeoxyribonucleotides for a variety of human cancers, including acute myelogenous leukemia (AML). Within overlapping regions, we found greater than 95% identity between the Rhesus and human p53 sequences, and greater than 98% identity between Rhesus and African green monkey p53 sequences. The deduced amino acid (aa) sequence of the p53 protein is highly conserved between human and Rhesus monkey, with only 18 minor differences in 393 aa.