Optimal therapy for enterococcal endocarditis

• Published in: The American journal of medicine Vol. 76; no. 2; pp. 186 - 191
• Main Authors: Herzstein, Jessica, Ryan, John L., Mangi, Richard J., Greco, Thomas P., Andriole, Vincent T.
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 01.01.1984; Elsevier
• Subjects: Aminoglycosides - therapeutic use; Anti-Bacterial Agents - therapeutic use; Antibacterial agents; Antibiotics. Antiinfectious agents. Antiparasitic agents; Biological and medical sciences; Drug Therapy, Combination; Endocarditis, Bacterial - drug therapy; Endocarditis, Bacterial - surgery; Enterococcus faecalis; Female; Humans; Intestines - microbiology; Male; Medical sciences; Middle Aged; Penicillins - administration & dosage; Pharmacology. Drug treatments; Streptococcal Infections - drug therapy; Streptococcal Infections - surgery; Vancomycin - administration & dosage; Human; Cardiovascular disease; Review; Infection; Streptococcus D; Antibiotic; Chemotherapy; Treatment; Aminoglycoside; Heart disease; Surgery; Endocarditis; Bacteriosis
• ISSN: 0002-9343; 1555-7162
• DOI: 10.1016/0002-9343(84)90772-1

Enterococcal endocarditis accounts for an increasing proportion of cases of endocarditis in recent years. The combination of a penicillin and an aminoglycoside has become an accepted standard of treatment for this disease. However, the optimal choice of antibiotics, duration of therapy, and timing of surgical intervention remain controversial. This study reviews the presentation, clinical course, treatment, and outcome in 37 patients with 42 separate episodes of enterococcal endocarditis at four Yale University hospitals. Patients treated with aminoglycosides and penicillins or vancomycin had significantly better outcomes than those who did not receive aminoglycosides. However, the duration of aminoglycoside therapy (more than four versus less than four weeks) did not appear to affect outcome significantly. These results suggest that excellent cure rates may be achieved after treatment for less than four weeks with an aminoglycoside in combination with penicillin or vancomycin, thus potentially avoiding significant renal and vestibular toxicity.