Prognostic Value of Initial Tumor Parameters After Metastatic Relapse

Classical prognostic factors of breast cancer are correlated to disease-free survival and overall survival (OS); their precise role is less known on metastatic disease. A total of 511 breast cancer patients without initial metastasis were treated. OS was divided in time to distant recurrence and met...

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Published inCancer investigation Vol. 29; no. 9; pp. 635 - 643
Main Authors Planchat, E., Durando, X., Abrial, C., Thivat, E., Mouret-Reynier, M. A., Ferrière, J. P., Pomel, C., Kwiatkowski, F., Chollet, P., Nabholtz, J. M.
Format Journal Article
LanguageEnglish
Published England Informa Healthcare 01.11.2011
Taylor & Francis
Subjects
Adult
Aged
Disease-Free Survival
Female
Humans
Immunohistochemistry
Initial parameters
Male
Metastatic breast cancer
Middle Aged
Neoplasm Grading
Neoplasm Metastasis
Neoplasms - metabolism
Neoplasms - pathology
Overall survival
Predictive factors
Prognosis
Prognostic factors
Recurrence
Survival Rate
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Summary:Classical prognostic factors of breast cancer are correlated to disease-free survival and overall survival (OS); their precise role is less known on metastatic disease. A total of 511 breast cancer patients without initial metastasis were treated. OS was divided in time to distant recurrence and metastatic survival (MS). Age, Scarff-Bloom-Richardson (SBR) grade, hormone receptor, axillary node involvement, and Nottingham prognostic index predicted MS in univariate analysis. Multivariate analysis retained age, SBR grade, and axillary lymph node involvement as significant independent prognostic factors. Interactions are still present between initial parameters and MS. The clinician has to take into account for treatment choice.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:0735-7907
1532-4192
DOI:10.3109/07357907.2011.621911