Interleukin-1β, interleukin-6, epidermal growth factor and transforming growth factor-α are elevated in the brain from parkinsonian patients

• Published in: Neuroscience letters Vol. 180; no. 2; pp. 147 - 150
• Main Authors: Mogi, Makio, Harada, Minoru, Kondo, Tomoyshi, Riederer, Peter, Inagaki, Hirofumi, Minami, Masayasu, Nagatsu, Toshiharu
• Format: Journal Article
• Language: English
• Published: Shannon Elsevier Ireland Ltd 24.10.1994; Elsevier
• Subjects: Aged; Aged, 80 and over; Biological and medical sciences; Brain; Brain Chemistry; Caudate Nucleus - chemistry; Cerebral Cortex - chemistry; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases; Dopamine - analysis; Enzyme-Linked Immunosorbent Assay; Epidermal growth factor; Epidermal Growth Factor - analysis; Female; Humans; Interleukin-1 - analysis; Interleukin-1β; Interleukin-6; Interleukin-6 - analysis; Male; Medical sciences; Middle Aged; Nerve Tissue Proteins - analysis; Neurology; Parkinson Disease - metabolism; Parkinson's disease; Putamen - chemistry; Transforming Growth Factor alpha - analysis; Transforming growth factor-α; Brain; Epidermal growth factor; Parkinson's disease; Interleukin-1β; Transforming growth factor-α; Interleukin-6; Human; Nervous system diseases; Cerebral cortex; Pathophysiology; Cytokine; Trophic factor; Parkinson disease; Interleukin 1β; Basal ganglion; Gene expression; Putamen; Cerebral disorder; Interleukin 6; Caudate nucleus; Central nervous system disease; Degenerative disease; Transforming growth factor α
• ISSN: 0304-3940; 1872-7972
• DOI: 10.1016/0304-3940(94)90508-8

Interleukin (IL)-1β, IL-6, epidermal growth factor (EGF), and transforming growth factor-α (TGF-α) were measured for the first time in the brain (caudate nucleus, putamen and cerebral cortex) from control and parkinsonian patients by highly sensitive sandwich enzyme immunoassays. The concentrations of IL-1β, IL-6, EGF, and TGF-α in the dopaminergic, striatal regions were significantly higher in parkinsonian patients than those in controls, whereas those in the cerebral cortex did not show significant differences between parkinsonian and control subjects. Since these cytokines and growth factors may play important roles as neurotrophic factors in the brain, the present results suggest that they may be produced as compensatory responses in the nigrostriatal dopaminergic regions in Parkinson's disease, and may be related, at least in part, to the process of neurodegeneration in Parkinson's disease.