HTLV-related markers in a hungarian patient with adult T-cell leukemia

Monoclonal integration of DNA sequences related to, but not identical to HTLV-I provirus was detected in the peripheral blood lymphocytes of a Hungarian male suffering from ATL. The patient and his parents showed serological cross-reactivity with both HTLV-I and HTLV-II groupspecific antigens. Restr...

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Published inLeukemia research Vol. 16; no. 11; pp. 1125 - 1131
Main Authors Kiss, Jolàn, Telek, Béla, Tóth, Ferenc D., Rejtő, László, Surányi, Péter, Rák, Kálmán
Format Journal Article
LanguageEnglish
Published Oxford Elsevier Ltd 01.11.1992
Elsevier Science
Subjects
Adolescent
AIDS/HIV
Antigens, Viral
ATL
Biological and medical sciences
Blotting, Southern
Cross Reactions
cross-reacting antibodies
DNA, Viral - analysis
familial cluster of carriers
Genetic Markers
Hematologic and hematopoietic diseases
HTLV-related proviral DNA
Human T-lymphotropic virus 1 - genetics
Human T-lymphotropic virus 1 - immunology
Humans
Hungary
Leukemia, T-Cell - microbiology
Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis
Male
Medical sciences
Hungary
Europe
IFA, immunofluorescence assay
ATL, adult T-cell leukemia
PBMC, peripheral blood mononuclear cells
Con-A, concavalin-A
FITC, fluorescein isothiocyanate
ATL
familial cluster of carriers
cross-reacting antibodies
HTLV-related proviral DNA
HTLV, human T-cell leukemia/lymphoma virus
RIPA, radioimmunoprecipitation assay, LTR, long terminal repeat
Human
Virus
Case study
Adult T cell leukemia
Lymphoproliferative syndrome
Adolescent
Retroviridae
Biological marker
Malignant hemopathy
HTLV-I virus
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Summary:Monoclonal integration of DNA sequences related to, but not identical to HTLV-I provirus was detected in the peripheral blood lymphocytes of a Hungarian male suffering from ATL. The patient and his parents showed serological cross-reactivity with both HTLV-I and HTLV-II groupspecific antigens. Restriction enzyme analysis with EcoR1, Pstl, BamH1, HindIII and Sacl revealed structural similarity of the provirus integrated in the DNA of ATL cells to HTLV-I but not to HTLV-II. Data suggest that this provirus and HTLV-I are similar to each other along gag and pol regions, but they are different in the env region.
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ISSN:0145-2126
1873-5835
DOI:10.1016/0145-2126(92)90051-8