The analysis of several nonopiate narcotic analgesics and cocaine in serum using high-performance liquid chromatography

This paper describes a procedure for the quantitative determination of methadone, meperidine, normeperidine, pentazocine, propoxyphene, norpropoxyphene, and dextromoramide in serum down to levels of 10 micrograms/L and of cocaine down to 25 micrograms/L. The procedure involves a simple extraction te...

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Bibliographic Details
Published inJournal of analytical toxicology Vol. 11; no. 6; p. 269
Main Authors Hackett, L P, Dusci, L J, Ilett, K F
Format Journal Article
LanguageEnglish
Published England 01.11.1987
Subjects
Analgesics, Opioid - blood
Chromatography, High Pressure Liquid
Cocaine - blood
Humans
Indicators and Reagents
Methadone - blood
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Summary:This paper describes a procedure for the quantitative determination of methadone, meperidine, normeperidine, pentazocine, propoxyphene, norpropoxyphene, and dextromoramide in serum down to levels of 10 micrograms/L and of cocaine down to 25 micrograms/L. The procedure involves a simple extraction technique and high-performance liquid chromatography and is suitable for use in overdose drug screening, forensic toxicology, therapeutic drug monitoring, and pharmacokinetic studies.
ISSN:0146-4760
DOI:10.1093/jat/11.6.269