Antibody reactivity against trophoblast and trophoblast products

• Published in: Journal of reproductive immunology Vol. 8; no. 4; pp. 347 - 352
• Main Authors: Johnson, P.M., Cheng, H.M., Stevens, V.C., Matangkasombut, P.
• Format: Journal Article
• Language: English
• Published: Shannon Elsevier Ireland Ltd 01.12.1985; Elsevier Science
• Subjects: anti-trophoblast; antibodies; Antibodies - analysis; Antibodies - immunology; Biological and medical sciences; Birth control; Cell Membrane - immunology; Chorionic Gonadotropin - immunology; Chorionic Gonadotropin - metabolism; Chorionic Gonadotropin, beta Subunit, Human; Enzyme-Linked Immunosorbent Assay; Female; Gynecology. Andrology. Obstetrics; hCG; Humans; infertility; Infertility, Female - blood; Infertility, Female - immunology; Medical sciences; Peptide Fragments - immunology; Peptide Fragments - metabolism; Placenta - cytology; Placenta - immunology; Pregnancy Proteins - immunology; Pregnancy-Specific beta 1-Glycoproteins - immunology; SP1; Sterility. Assisted procreation; Trophoblasts - cytology; Trophoblasts - immunology; Trophoblasts - metabolism; World Health Organization; antibodies; infertility; anti-trophoblast; SP1; hCG; Human; Trophoblaste; Natural antibody; Immunology; Placenta; Female sterility; Pregnancy specific glycoprotein SP1; Glycoprotein hormone; HCG
• ISSN: 0165-0378; 1872-7603
• DOI: 10.1016/0165-0378(85)90009-9

Sensitive immunoassays have been applied to WHO reference bank sera from fertile and infertile women in order to assess any naturally occurring antibody reactive with isolated human placental trophoblast membranes or two separate trophoblast protein products (hCG and SPI). A very low incidence of antibody reactive with solubilised trophoblast membrane was detected, and no significant antibody to either hCG or SP1 could be detected. Infertile states represented within this serum bank appear unlikely to involve adverse immune reactions to trophoblast.