Quantitative methods for assessing a synergistic or potentiated genotoxic response

The problem of assessing chemical interactions in studies of genotoxicity is discussed. Attention is focused on assessing possible synergism or potentiation when the observed genotoxic response is binary (yes-no). Different forms of enhancement are distinguished based upon different assumptions on t...

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Bibliographic Details
Published inMutation Research/Environmental Mutagenesis and Related Subjects Vol. 216; no. 1; pp. 1 - 8
Main Authors Piegorsch, Walter W., Margolin, Barry H.
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier B.V 01.02.1989
Subjects
Aminacrine - toxicity
Binary data
Caffeine - toxicity
Chromates - toxicity
Chromosome aberrations
Drug Synergism
Factorial experiments
Fluctuation assay
Hydroxyurea - toxicity
Interaction
Models, Biological
Mutagenicity Tests - standards
Potassium Compounds
Simple independent action
Simple similar action
Statistics as Topic
X-Rays
Interaction
Simple independent action
Binary data
Simple similar action
Fluctuation assay
Chromosome aberrations
Factorial experiments
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Summary:The problem of assessing chemical interactions in studies of genotoxicity is discussed. Attention is focused on assessing possible synergism or potentiation when the observed genotoxic response is binary (yes-no). Different forms of enhancement are distinguished based upon different assumptions on the genotoxic activity of the experimental treatments. A generalized linear statistical model is considered that links the probability of the binary response to the doses, and data-analytic strategies are described for detecting synergy and potentiation in factorially designed experiments. This approach is illustrated with a series of analyses of various genotoxicity data-sets.
ISSN:0165-1161
0027-5107
DOI:10.1016/0165-1161(89)90017-4