Bombesin derivative radiolabeled with technetium-99m as agent for tumor identification

• Published in: Bioorganic & medicinal chemistry letters Vol. 20; no. 21; pp. 6182 - 6184
• Main Authors: de Barros, André Luís Branco, Mota, Luciene das Graças, Ferreira, Carolina de Aguiar, Oliveira, Mônica Cristina de, Góes, Alfredo Miranda de, Cardoso, Valbert Nascimento
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier Ltd 01.11.2010; Elsevier
• Subjects: Animals; Anura; Biological and medical sciences; Bombesin; Bombesin - analogs & derivatives; Bombesin - chemistry; Carcinoma, Ehrlich Tumor - diagnostic imaging; Carcinoma, Ehrlich Tumor - metabolism; Contrast media. Radiopharmaceuticals; Diagnosis agents; Gastrin release peptide; Indicators and Reagents; Injections, Intravenous; Medical sciences; Mice; Mice, Inbred BALB C; Muscle, Skeletal - metabolism; Neoplasms - diagnostic imaging; Organotechnetium Compounds - chemical synthesis; Organotechnetium Compounds - pharmacokinetics; Peptide Fragments - chemical synthesis; Peptide Fragments - pharmacokinetics; Pharmacology. Drug treatments; Radionuclide Imaging; Radiopharmaceuticals - chemical synthesis; Radiopharmaceuticals - pharmacokinetics; Spectrometry, Mass, Electrospray Ionization; Technetium; Technetium-99m; Tissue Distribution; Tumor; Diagnosis agents; Tumor; Bombesin; Gastrin release peptide; Technetium-99m; Adenocarcinoma; Intravenous administration; Oligopeptides; Peptides; Spontaneous; Peptide hormone; Tissue; Gastrointestinal hormone; Technetium Complexes; Scintigraphic agent; Diagnosis; Radioisotopic product; Radiolabelling; Rodentia; Transition metal Complexes; Malignant tumor; Diagnostic agent; Gastrin releasing peptide; Mammary gland diseases; Vertebrata; Mammalia; Mouse; Polypeptide; Distribution; Ehrlich ascites tumor; Pharmacokinetics; Cancer
• ISSN: 0960-894X; 1464-3405
• DOI: 10.1016/j.bmcl.2010.08.124

Preparation of technetium-labeled bombesin derivative for tumor identification. A bombesin derivative was successfully radiolabeled in high labeling yield. Biodistribution studies and scintigraphic images in Ehrlich tumor-bearing mice were performed. This compound showed high accumulation in tumor tissue with high tumor-to-muscle and tumor-to-blood ratios. Thus, 99mTc-HYNIC-Bombesin (7–14) could be used as an agent for tumor diagnosis.