Melatonin binding to the anteroventral and anterodorsal thalamic nuclei in the rat

Pineal melatonin is a putative humoral coordinator of various circadian body rhythms. Rather few loci in the brain contain such a density of melatonin receptors that specific binding can be demonstrated by autoradiography. In this study we measured, using in vitro receptor autoradiography, displacea...

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Bibliographic Details
Published inNeuroscience letters Vol. 143; no. 1-2; p. 219
Main Authors Lindroos, O F, Leinonen, L M, Laakso, M L
Format Journal Article
LanguageEnglish
Published Ireland 31.08.1992
Subjects
Animals
Circadian Rhythm
Learning - physiology
Limbic System - metabolism
Male
Melatonin - metabolism
Memory - physiology
Paraventricular Hypothalamic Nucleus - metabolism
Rats
Rats, Wistar
Receptors, Melatonin
Receptors, Neurotransmitter - metabolism
Suprachiasmatic Nucleus - metabolism
Thalamic Nuclei - metabolism
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Summary:Pineal melatonin is a putative humoral coordinator of various circadian body rhythms. Rather few loci in the brain contain such a density of melatonin receptors that specific binding can be demonstrated by autoradiography. In this study we measured, using in vitro receptor autoradiography, displaceable binding of iodo-melatonin to the anteroventral and anterodorsal thalamic nuclei of Wistar rats (0.6-1.4 fmol/mg protein at 100 pM ligand concentration). These nuclei of the limbic system have direct connections with the retina and they participate in learning and memory functions.
ISSN:0304-3940
DOI:10.1016/0304-3940(92)90269-D