Sneddon's syndrome: clinical and immunohistochemical findings

• Published in: Clinical neurology and neurosurgery Vol. 96; no. 4; pp. 310 - 313
• Main Authors: Fetoni, Vincenza, Berti, Emilio, Cecca, Emanuela, Carella, Francesco, Sinico, Renato Alberto, Girotti, Floriano
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier B.V 01.11.1994; Elsevier Science
• Subjects: Adult; Aged; Antibodies, Anticardiolipin - analysis; Antiphospholipid antibodies; Antiphospholipid Syndrome - genetics; Antiphospholipid Syndrome - immunology; Antiphospholipid Syndrome - pathology; Autoantibodies - analysis; Biological and medical sciences; Biopsy; Blood Coagulation Factors - analysis; Brain Ischemia - genetics; Brain Ischemia - immunology; Brain Ischemia - pathology; Diagnosis, Differential; Female; Humans; Livedo racemosa; Lupus Coagulation Inhibitor - analysis; Medical sciences; Middle Aged; Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis; Skin - immunology; Skin - pathology; Skin Diseases, Vascular - genetics; Skin Diseases, Vascular - immunology; Skin Diseases, Vascular - pathology; Sneddon's syndrome; Livedo racemosa; Antiphospholipid antibodies; Sneddon's syndrome; Human; Immunohistochemistry; Stroke; Skin disease; Nervous system diseases; Multiple; Cerebrovascular insufficiency; Autoantibody; Phospholipid; Cardiovascular disease; Exploration; Livedo reticularis; Cerebral disorder; Arterial disease; Vascular disease; Pathology; Biopsy; Systemic disease; Central nervous system disease; Skin; Coagulation factor; Cerebrovascular disease
• ISSN: 0303-8467; 1872-6968
• DOI: 10.1016/0303-8467(94)90120-1

Results of immunological studies on skin biopsies of 5 patients with Sneddon's syndrome are reported. Also studied were coagulation factors and autoantibodies believed to play a role in this syndrome. Hemostasis was normal except for a mild increase of fibrinogen in one subject; lupus anticoagulant (LAC) and anticardiolipin antibodies were negative in all. The skin biopsies ruled out systemic vasculitis and vasculitis in association with connective tissue diseases. Sneddon's syndrome is a peculiar clinico-pathological condition, probably with several etiologies, but is distinct from primary antiphospholipid syndrome.