Effects of norepinephrine and serotonin uptake inhibitors on the schedule-controlled behavior of the pigeon

• Published in: Pharmacology, biochemistry and behavior Vol. 20; no. 3; pp. 391 - 395
• Main Authors: Leander, J.David, Carter, Richard B.
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 01.01.1984; Elsevier Science
• Subjects: Amitriptyline - pharmacology; Animals; Antidepressants; Antidepressive Agents, Tricyclic - pharmacology; Biological and medical sciences; Clomipramine - pharmacology; Columbidae; Conditioning, Operant - drug effects; Desipramine - pharmacology; Doxepin - pharmacology; Fluoxetine - analogs & derivatives; Fluoxetine - pharmacology; Iprindole - pharmacology; Male; Medical sciences; Multiple fixed ratio, fixed-interval; Neuropharmacology; Norepinephrine - metabolism; Norepinephrine uptake inhibitors; Operant behavior; Pharmacology. Drug treatments; Pigeons; Protriptyline - pharmacology; Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease); Psychology. Psychoanalysis. Psychiatry; Psychopharmacology; Reinforcement Schedule; Serotonin Antagonists - pharmacology; Multiple fixed ratio, fixed-interval; Operant behavior; Antidepressants; Pigeons; Norepinephrine uptake inhibitors; Operant conditioning; Serotonin antagonist; Catecholamine; Tricyclic compound; Pigeon; Intramuscular administration; Vertebrata; Adrenergic blocking agent; Acquisition process; Animal; Antidepressant agent; Norepinephrine; Behavior; Aves; Mechanism of action
• ISSN: 0091-3057; 1873-5177
• DOI: 10.1016/0091-3057(84)90277-6

The effects of nortriptyline, amitriptyline, desipramine, chlorimipramine, protriptyline, doxepin, nisoxetine, fluoxetine and iprindole were determined on responding by pigeons under a multiple fixed-ratio 30-response, fixed-interval 10-minute schedule of grain presentation. Those drugs which have been shown to block uptake of norepinephrine decreased fixed-interval quarter-life values. Those which are considered most selective as norepinephrine uptake inhibitors also increased overall fixed-interval responding. These increases in fixed-interval responding, both on local and overall rates, in pigeons appear to be due to the actions of these drugs to inhibit uptake of norepinephrine rather than to other actions.