Ethanol and acetaldehyde potentiate the clastogenicity of ultraviolet light, methyl methanesulfonate, mitomycin C and bleomycin in Chinese hamster ovary cells

• Published in: Mutation Research/Environmental Mutagenesis and Related Subjects Vol. 216; no. 2; pp. 93 - 99
• Main Authors: Lin, Ying-Chun, Ho, I-Ching, Lee, Te-Chang
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.04.1989
• Subjects: Acetaldehyde; Acetaldehyde - toxicity; Animals; Bleomycin; Cell Line; Chromosome Aberrations; Clastogenicity; Cricetinae; Cricetulus; Drug Synergism; Ethanol; Ethanol - toxicity; Female; Methyl Methanesulfonate; Mitomycin; Mitomycins; Mutagens; Ovary; Ultraviolet Rays - adverse effects; Ethanol; Clastogenicity; Acetaldehyde

Ethanol itself did not induce any apparent chromosome aberrations in Chinese hamster ovary cells. However, posttreatment with ethanol potentiated the chromosome aberrations induced by ultraviolet light (UV), methyl methanesulfonate (MMS), mitomycin C (MMC) or bleomycin (BLM). Chromatid exchanges wer...