Ethanol and acetaldehyde potentiate the clastogenicity of ultraviolet light, methyl methanesulfonate, mitomycin C and bleomycin in Chinese hamster ovary cells

Ethanol itself did not induce any apparent chromosome aberrations in Chinese hamster ovary cells. However, posttreatment with ethanol potentiated the chromosome aberrations induced by ultraviolet light (UV), methyl methanesulfonate (MMS), mitomycin C (MMC) or bleomycin (BLM). Chromatid exchanges wer...

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Published inMutation Research/Environmental Mutagenesis and Related Subjects Vol. 216; no. 2; pp. 93 - 99
Main Authors Lin, Ying-Chun, Ho, I-Ching, Lee, Te-Chang
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier B.V 01.04.1989
Subjects
Acetaldehyde
Acetaldehyde - toxicity
Animals
Bleomycin
Cell Line
Chromosome Aberrations
Clastogenicity
Cricetinae
Cricetulus
Drug Synergism
Ethanol
Ethanol - toxicity
Female
Methyl Methanesulfonate
Mitomycin
Mitomycins
Mutagens
Ovary
Ultraviolet Rays - adverse effects
Ethanol
Clastogenicity
Acetaldehyde
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Summary:Ethanol itself did not induce any apparent chromosome aberrations in Chinese hamster ovary cells. However, posttreatment with ethanol potentiated the chromosome aberrations induced by ultraviolet light (UV), methyl methanesulfonate (MMS), mitomycin C (MMC) or bleomycin (BLM). Chromatid exchanges were predominantly increased in cultures treated with UV, MMS or MMC and then with ethanol, whereas chromosome breaks and chromatid exchange were the major types of aberrations increased in the cultures treated with BLM and ethanol. Posttreatment with acetaldehyde, the major metabolite of ethanol, also potentiated the chromosome aberrations induced by UV, MMS, MMC or BLM. The main types of aberrations potentiated by posttreatment with acetaldehyde were similar to those by posttreatment with ethanol.
ISSN:0165-1161
0027-5107
DOI:10.1016/0165-1161(89)90009-5